Five priority areas for improving medications development for alcohol use disorder and promoting their routine use in clinical practice.

RZ Litten, DE Falk, ML Ryan, J Fertig… - Alcoholism: Clinical and …, 2020 - psycnet.apa.org
The article discusses about the priority areas for improving medications development for
alcohol use disorder and promoting their routine use in clinical practice. During the past 25 …

[HTML][HTML] A Brief Overview of Ethanol Tolerance and Its Potential Association with Circadian Rhythm in Drosophila

SK Peterson, ST Ahmad - International Journal of Molecular Sciences, 2024 - mdpi.com
Alcohol consumption and addiction remain global health concerns, with significant loss of
productivity, morbidity, and mortality. Drosophila melanogaster, a widely used model …

Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila

M Kanno, S Hiramatsu, S Kondo, H Tanimoto… - Scientific reports, 2021 - nature.com
Dysregulated motivation to consume psychoactive substances leads to addictive behaviors
that often result in serious health consequences. Understanding the neuronal mechanisms …

Developmental alcohol exposure in Drosophila: effects on adult phenotypes and gene expression in the brain

SS Mokashi, V Shankar, RA MacPherson… - Frontiers in …, 2021 - frontiersin.org
Fetal alcohol exposure can lead to developmental abnormalities, intellectual disability, and
behavioral changes, collectively termed fetal alcohol spectrum disorder (FASD). In 2015, the …

Alcohol, neuronal plasticity, and mitochondrial trafficking

J Hernandez, KR Kaun - Proceedings of the National …, 2022 - National Acad Sciences
Consumption of alcohol creates a sense of euphoria, reduces inhibition, and increases
sociability and impulsivity (1). The age at which alcohol is first experienced is a key factor …

Pharmacological targeting of the GABAB receptor alters Drosophila's behavioural responses to alcohol

DC Ranson, SS Ayoub, O Corcoran… - Addiction …, 2020 - Wiley Online Library
When exposed to ethanol, Drosophila melanogaster display a variety of addiction‐like
behaviours similar to those observed in mammals. Sensitivity to ethanol can be quantified by …

Modulation of the Drosophila transcriptome by developmental exposure to alcohol

TV Morozova, V Shankar, RA MacPherson… - BMC genomics, 2022 - Springer
Background Prenatal exposure to ethanol can cause fetal alcohol spectrum disorder
(FASD), a prevalent, preventable pediatric disorder. Identifying genetic risk alleles for FASD …

Ethanol behavioral responses in Drosophila

KM Nuñez, JL Catalano… - Cold Spring Harbor …, 2023 - cshprotocols.cshlp.org
Drosophila melanogaster is a powerful genetic model for investigating the mechanisms
underlying ethanol-induced behaviors, metabolism, and preference. Ethanol-induced …

TBI and Tau Loss of Function Both Affect Naïve Ethanol Sensitivity in Drosophila

V Hoxha, G Shrestha, N Baloch, S Collevechio… - International Journal of …, 2024 - mdpi.com
Traumatic brain injury (TBI) is associated with alcohol abuse and higher ethanol sensitivity
later in life. Currently, it is poorly understood how ethanol sensitivity changes with time after …

Neuroecology of Alcohol Preference in Drosophila

IW Keesey, BS Hansson - Annual Review of Entomology, 2022 - annualreviews.org
In this review, we highlight sources of alcohols in nature, as well as the behavioral and
ecological roles that these fermentation cues play in the short lifespan of Drosophila …