Background and purpose Migraine and thyroid dysfunction, particularly hypothyroidism, are
common medical conditions and are known to have high heritability. Thyroid function …

Rank aggregation (RA), the process of combining multiple ranked lists into a single ranking,
has played an important role in integrating information from individual genomic studies that …

The parallel rise in obesity and male infertility in modern societies necessitates the
identification of susceptibility genes underlying these interconnected health issues. In our …

The rationale of the drug design method is generally focused on the designing of “magic
bullets” that acts on individual drug targets. This idea of “one gene, one target, one disease” …

More than half a century of research focused on ischemic brain injury mechanisms has
failed to yield a widely accepted neuroprotective drug for the treatment of acute ischemic …

Knowledge of similarities among diseases can contribute to uncovering common genetic
mechanisms. Based on ranked gene lists, a couple of similarity measures were proposed in …

Migraine and thyroid dysfunction, particularly hypothyroidism, are among the most common
disabling diseases. They affect a significant proportion of the population globally, and their …

Migraine is the most common brain disorder, affecting almost 14% of the adult population,
yet its molecular mechanisms and pathogenic tissue (s) remain unclear. In this thesis, I have …

Current research on Alzheimer's disease (AD) predominantly focuses on targeting beta-
amyloid (Aß) plaques, as these are thought to be the initiators of disease. Approaching AD …

The current trend in genetic research is the study of omics data as a whole, either combining
studies or omics techniques. This raises the need for new robust statistical methods that can …