Capsaicin ameliorate pulmonary fibrosis via antioxidant Nrf-2/PPAR-γ pathway activation and inflammatory TGF-β1/NF-κB/COX II pathway inhibition

WH Abdulaal, HZ Asfour, N Helmi… - Frontiers in …, 2024 - frontiersin.org
Bleomycin is an effective antibiotic with a significant anticancer properties, but its use is
limited due to its potential to induce dose-dependent pulmonary fibrosis. Therefore, this …

Qingfei Tongluo Mixture Attenuates Bleomycin‐Induced Pulmonary Inflammation and Fibrosis through mTOR‐Dependent Autophagy in Rats

S Ge, Z Guo, T Xiao, P Sun, B Yang… - Mediators of …, 2024 - Wiley Online Library
As an interstitial fibrosis disease characterized by diffuse alveolitis and structural alveolar
disorders, idiopathic pulmonary fibrosis (IPF) has high lethality but lacks limited therapeutic …

Carvedilol induces pyroptosis through NLRP3-caspase1-ASC inflammasome by nuclear migration of NF-κB in prostate cancer models

Y Zeng, M Li, S Wu, C Xu - Molecular Biology Reports, 2024 - Springer
Background Pyroptosis is an inflammatory type of programmed cell death, and could
overcome the drug-resistance induced by anti-apoptotic effect of cancers. Carvedilol (CVL) …