Mechanisms of bone development and repair
A Salhotra, HN Shah, B Levi… - Nature reviews Molecular …, 2020 - nature.com
Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …
formation of the body scaffold. The repair potential of bone and its surrounding …
Estrogens and androgens in skeletal physiology and pathophysiology
M Almeida, MR Laurent, V Dubois… - Physiological …, 2017 - journals.physiology.org
Estrogens and androgens influence the growth and maintenance of the mammalian
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …
Transforming growth factor-β in stem cells and tissue homeostasis
Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes
F Lei, M Li, T Lin, H Zhou, F Wang, X Su - Acta biomaterialia, 2022 - Elsevier
Periodontitis is the primary cause of tooth loss, but there is no effective treatment to repair
inflammatory bone loss in periodontitis. Exosomes emerge as essential paracrine factors of …
inflammatory bone loss in periodontitis. Exosomes emerge as essential paracrine factors of …
Wnt pathway in bone repair and regeneration–what do we know so far
KS Houschyar, C Tapking, MR Borrelli… - Frontiers in cell and …, 2019 - frontiersin.org
Wnt signaling plays a central regulatory role across a remarkably diverse range of functions
during embryonic development, including those involved in the formation of bone and …
during embryonic development, including those involved in the formation of bone and …
Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors
Abstract In the human body, 50–70 billion cells die every day, resulting in the generation of a
large number of apoptotic bodies. However, the detailed biological role of apoptotic bodies …
large number of apoptotic bodies. However, the detailed biological role of apoptotic bodies …
Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease
AR Williams, JM Hare - Circulation research, 2011 - Am Heart Assoc
Mesenchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-
renewal and differentiation with a broad tissue distribution. Initially described in bone …
renewal and differentiation with a broad tissue distribution. Initially described in bone …
Role of Wnt signaling and sclerostin in bone and as therapeutic targets in skeletal disorders
Wnt signaling and its bone tissue–specific inhibitor sclerostin are key regulators of bone
homeostasis. The therapeutic potential of anti-sclerostin antibodies (Scl-Abs), for bone mass …
homeostasis. The therapeutic potential of anti-sclerostin antibodies (Scl-Abs), for bone mass …
[HTML][HTML] Biomaterial-induced pathway modulation for bone regeneration
Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …
Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency
There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …