Mechanisms of bone development and repair

A Salhotra, HN Shah, B Levi… - Nature reviews Molecular …, 2020 - nature.com
Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Estrogens and androgens in skeletal physiology and pathophysiology

M Almeida, MR Laurent, V Dubois… - Physiological …, 2017 - journals.physiology.org
Estrogens and androgens influence the growth and maintenance of the mammalian
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …

Transforming growth factor-β in stem cells and tissue homeostasis

X Xu, L Zheng, Q Yuan, G Zhen, JL Crane, X Zhou… - Bone research, 2018 - nature.com
Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …

Treatment of inflammatory bone loss in periodontitis by stem cell-derived exosomes

F Lei, M Li, T Lin, H Zhou, F Wang, X Su - Acta biomaterialia, 2022 - Elsevier
Periodontitis is the primary cause of tooth loss, but there is no effective treatment to repair
inflammatory bone loss in periodontitis. Exosomes emerge as essential paracrine factors of …

Wnt pathway in bone repair and regeneration–what do we know so far

KS Houschyar, C Tapking, MR Borrelli… - Frontiers in cell and …, 2019 - frontiersin.org
Wnt signaling plays a central regulatory role across a remarkably diverse range of functions
during embryonic development, including those involved in the formation of bone and …

Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors

D Liu, X Kou, C Chen, S Liu, Y Liu, W Yu, T Yu, R Yang… - Cell research, 2018 - nature.com
Abstract In the human body, 50–70 billion cells die every day, resulting in the generation of a
large number of apoptotic bodies. However, the detailed biological role of apoptotic bodies …

Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease

AR Williams, JM Hare - Circulation research, 2011 - Am Heart Assoc
Mesenchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-
renewal and differentiation with a broad tissue distribution. Initially described in bone …

Role of Wnt signaling and sclerostin in bone and as therapeutic targets in skeletal disorders

F Marini, F Giusti, G Palmini, ML Brandi - Osteoporosis International, 2023 - Springer
Wnt signaling and its bone tissue–specific inhibitor sclerostin are key regulators of bone
homeostasis. The therapeutic potential of anti-sclerostin antibodies (Scl-Abs), for bone mass …

[HTML][HTML] Biomaterial-induced pathway modulation for bone regeneration

S Vermeulen, ZT Birgani, P Habibovic - Biomaterials, 2022 - Elsevier
Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

RJ McMurray, N Gadegaard, PM Tsimbouri… - Nature materials, 2011 - nature.com
There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …