Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms

Y Wang, G Zhan, Z Cai, B Jiao, Y Zhao, S Li… - … & Biobehavioral Reviews, 2021 - Elsevier
Brain diseases, including neurodegenerative, cerebrovascular and neuropsychiatric
diseases, have posed a deleterious threat to human health and brought a great burden to …

European Academy of Neurology guidelines on the treatment of cluster headache

A May, S Evers, PJ Goadsby, M Leone… - European Journal of …, 2023 - Wiley Online Library
Abstract Background and Purpose Cluster headache is a relatively rare, disabling primary
headache disorder with a major impact on patients' quality of life. This work presents …

Noninvasive vagus nerve stimulation as acute therapy for migraine: the randomized PRESTO study

C Tassorelli, L Grazzi, M De Tommaso, G Pierangeli… - Neurology, 2018 - AAN Enterprises
Objective To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve
stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for the acute …

Phase 3 randomized, placebo-controlled study of galcanezumab in patients with chronic cluster headache: results from 3-month double-blind treatment

DW Dodick, PJ Goadsby, C Lucas, R Jensen… - …, 2020 - journals.sagepub.com
Objective To report efficacy and safety of galcanezumab in adults with chronic cluster
headache. Background Galcanezumab is a humanized monoclonal antibody that binds to …

Cluster headache

A May, TJ Schwedt, D Magis, P Pozo-Rosich… - Nature reviews Disease …, 2018 - nature.com
Cluster headache is an excruciating, strictly one-sided pain syndrome with attacks that last
between 15 minutes and 180 minutes and that are accompanied by marked ipsilateral …

Cluster headache pathophysiology—insights from current and emerging treatments

DY Wei, PJ Goadsby - Nature Reviews Neurology, 2021 - nature.com
Cluster headache is a debilitating primary headache disorder that affects approximately
0.1% of the population worldwide. Cluster headache attacks involve severe unilateral pain …

The trigeminal pathways

LM Terrier, N Hadjikhani, C Destrieux - Journal of Neurology, 2022 - Springer
The role of the trigeminal system in facial and dural sensitivity has been recognized for a
long time. More recently, the trigeminal system has also been considered a prominent actor …

Targeted vagus nerve stimulation for rehabilitation after stroke

ND Engineer, TJ Kimberley, CN Prudente… - Frontiers in …, 2019 - frontiersin.org
Stroke is a leading cause of disability worldwide, and in approximately 60% of individuals,
upper limb deficits persist 6 months after stroke. These deficits adversely affect the functional …

Primary headaches during lifespan

A Straube, A Andreou - The journal of headache and pain, 2019 - Springer
Primary headaches are one of the most prevalent neurological disorders and can occur
during a wide range of lifespan. Primary headaches, especially migraine, are cyclic …

Non-invasive vagus nerve stimulation (nVNS) for the preventive treatment of episodic migraine: the multicentre, double-blind, randomised, sham-controlled PREMIUM …

HC Diener, PJ Goadsby, M Ashina… - …, 2019 - journals.sagepub.com
Introduction Non-invasive vagus nerve stimulation (nVNS; gammaCore®) has the potential
to prevent migraine days in patients with migraine on the basis of mechanistic rationale and …