ROS signaling cascades: dual regulations for osteoclast and osteoblast

H Tao, G Ge, X Liang, W Zhang, H Sun… - Acta Biochimica et …, 2020 - academic.oup.com
Accumulating evidence indicates that intracellular reactive oxygen species (ROS)
production is highly involved in bone homeostasis by intervening osteoclast or osteoblast …

Influence of iron on bone homeostasis

E Balogh, G Paragh, V Jeney - Pharmaceuticals, 2018 - mdpi.com
Bone homeostasis is a complex process, wherein osteoclasts resorb bone and osteoblasts
produce new bone tissue. For the maintenance of skeletal integrity, this sequence has to be …

Regulating Type H Vessel Formation and Bone Metabolism via Bone‐Targeting Oral Micro/Nano‐Hydrogel Microspheres to Prevent Bone Loss

J Li, G Wei, G Liu, Y Du, R Zhang, A Wang… - Advanced …, 2023 - Wiley Online Library
Postmenopausal osteoporosis is one of the most prevalent skeletal disorders in women and
is featured by the imbalance between intraosseous vascularization and bone metabolism. In …

Long Bone Mineral Loss, Bone Microstructural Changes and Oxidative Stress After Eimeria Challenge in Broilers

YH Tompkins, P Teng, R Pazdro, WK Kim - Frontiers in Physiology, 2022 - frontiersin.org
The objective of this study was to evaluate the impact of coccidiosis on bone quality and
antioxidant status in the liver and bone marrow of broiler chickens. A total of 360 13-day old …

HO-1 in bone biology: potential therapeutic strategies for osteoporosis

X Zhou, W Yuan, X Xiong, Z Zhang, J Liu… - Frontiers in Cell and …, 2021 - frontiersin.org
Osteoporosis is a prevalent bone disorder characterized by bone mass reduction and
deterioration of bone microarchitecture leading to bone fragility and fracture risk. In recent …

Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress

L Ding, Z Gao, S Wu, C Chen, Y Liu, M Wang… - Natural Products and …, 2023 - Springer
Osteoporosis (OP), a systemic and chronic bone disease, is distinguished by low bone mass
and destruction of bone microarchitecture. Ginsenoside Compound-K (CK), one of the …

Targeting Sirt1, AMPK, Nrf2, CK2, and soluble guanylate cyclase with nutraceuticals: a practical strategy for preserving bone mass

MF McCarty, L Lewis Lujan, S Iloki Assanga - International Journal of …, 2022 - mdpi.com
There is a vast pre-clinical literature suggesting that certain nutraceuticals have the potential
to aid the preservation of bone mass in the context of estrogen withdrawal, glucocorticoid …

MicroRNAs: key regulators to understand osteoclast differentiation?

C Lozano, I Duroux-Richard, H Firat… - Frontiers in …, 2019 - frontiersin.org
MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that represent important
posttranscriptional regulators of protein-encoding genes. In particular, miRNAs play key …

Absence of dipeptidyl peptidase 3 increases oxidative stress and causes bone loss

C Menale, LJ Robinson, E Palagano… - Journal of Bone and …, 2019 - academic.oup.com
Controlling oxidative stress through the activation of antioxidant pathways is crucial in bone
homeostasis, and impairments of the cellular defense systems involved contribute to the …

CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced Osteoporosis via Modulating RANKL and ROS Signaling Pathways

J Li, J Liang, L Wu, Y Xu, C Xiao, X Yang… - Frontiers in …, 2022 - frontiersin.org
Osteoclasts are of hematopoietic lineage and have the ability to degrade mineralized bone
tissues. Abnormalities in osteoclastic activity under certain pathological conditions are …