Uncovering the Hidden Credentials of Brucella Virulence

RM Roop, IS Barton, D Hopersberger… - … and Molecular Biology …, 2021 - Am Soc Microbiol
Bacteria in the genus Brucella are important human and veterinary pathogens. The abortion
and infertility they cause in food animals produce economic hardships in areas where the …

Immune response triggered by Brucella abortus following infection or vaccination

EMS Dorneles, A Teixeira-Carvalho, MSS Araújo… - Vaccine, 2015 - Elsevier
Brucella abortus live vaccines have been used successfully to control bovine brucellosis
worldwide for decades. However, due to some limitations of these live vaccines, efforts are …

Immunity to brucellosis.

P Skendros, P Boura - Revue scientifique et technique …, 2013 - europepmc.org
Resistance to intracellular bacterial pathogens such as Brucella spp. relies on cell-mediated
immunity, which involves activation of the bactericidal mechanisms of antigen-presenting …

[HTML][HTML] Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide

E Barquero-Calvo, R Mora-Cartín, V Arce-Gorvel… - PLoS …, 2015 - journals.plos.org
Most bacterial infections induce the activation of polymorphonuclear neutrophils (PMNs),
enhance their microbicidal function, and promote the survival of these leukocytes for …

[HTML][HTML] Diagnostic role of mean platelet volume and neutrophil to lymphocyte ratio in childhood brucellosis

ŞE Bozdemir, YA Altıntop, S Uytun… - The Korean journal of …, 2017 - ncbi.nlm.nih.gov
Methods In this retrospective study, we reviewed hospital-records of 60 children with a
confirmed diagnosis of brucellosis in Kayseri between January 2013 and January 2016, and …

Cell and Tissue Tropism of Brucella spp.

TP Carvalho, LA Silva, TLL Castanheira… - Infection and …, 2023 - Am Soc Microbiol
Brucella spp. are facultatively intracellular bacteria that can infect, survive, and multiply in
various host cell types in vivo and/or in vitro. The genus Brucella has markedly expanded in …

[HTML][HTML] Immunosuppressive mechanisms in brucellosis in light of chronic bacterial diseases

JM Pellegrini, JP Gorvel, S Mémet - Microorganisms, 2022 - mdpi.com
Brucellosis is considered one of the major zoonoses worldwide, constituting a critical
livestock and human health concern with a huge socio-economic burden. Brucella genus, its …

Macrophage-elicited osteoclastogenesis in response to Brucella abortus infection requires TLR2/MyD88-dependent TNF-α production

MV Delpino, P Barrionuevo, GC Macedo… - Journal of leukocyte …, 2012 - academic.oup.com
Osteoarticular complications are common in human brucellosis, but the pathogenic
mechanisms involved are largely unknown. In this manuscript, we described an immune …

[HTML][HTML] Proinflammatory response of human endothelial cells to Brucella infection

MC Ferrero, J Bregante, MV Delpino, P Barrionuevo… - Microbes and …, 2011 - Elsevier
Although vascular pathologies such as vasculitis, endocarditis and mycotic aneurysms have
been described in brucellosis patients, the interaction of Brucella with the endothelium has …

Brucella abortus‐activated microglia induce neuronal death through primary phagocytosis

AM Rodríguez, MV Delpino, MC Miraglia… - Glia, 2017 - Wiley Online Library
Inflammation has long been implicated as a contributor to pathogenesis in neurobrucellosis.
Many of the associated neurocognitive symptoms of neurobrucellosis may be the result of …