Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …

Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …

Stress granules (SGs) and processing bodies (PBs) are non-membrane-enclosed RNA
granules that dynamically sequester translationally inactive messenger ribonucleoprotein …

In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Innate DNA sensing via the cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–
STING) mechanism surveys microbial invasion and cellular damage and thus participates in …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

The endoplasmic reticulum is an organelle with multiple functions. The synthesis of
transmembrane proteins and proteins that are to be secreted occurs in this organelle. Many …

Mitochondria participate in crucial cellular processes such as energy harvesting and
intermediate metabolism. Although mitochondria possess their own genome—a vestige of …

ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the
integrated stress response. The integrated stress response is triggered by phosphorylation …