Generating specificity in genome regulation through transcription factor sensitivity to chromatin
Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization
The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal …
understood. The transcription factor CTCF is a candidate regulator of chromosomal …
Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
CTCF shapes chromatin structure and gene expression in health and disease
B Dehingia, M Milewska, M Janowski, A Pękowska - EMBO reports, 2022 - embopress.org
CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …
Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors
Chromatin remodelling complexes evict, slide, insert or replace nucleosomes, which
represent an intrinsic barrier for access to DNA. These remodellers function in most aspects …
represent an intrinsic barrier for access to DNA. These remodellers function in most aspects …
Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler
NJ Abdulhay, LJ Hsieh, CP McNally… - Nature Structural & …, 2023 - nature.com
Nearly all essential nuclear processes act on DNA packaged into arrays of nucleosomes.
However, our understanding of how these processes (for example, DNA replication, RNA …
However, our understanding of how these processes (for example, DNA replication, RNA …
Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates
Nucleosomes are essential for proper chromatin organization and the maintenance of
genome integrity. Histones are post-translationally modified and often evicted at sites of …
genome integrity. Histones are post-translationally modified and often evicted at sites of …
[HTML][HTML] The nucleosome remodeling and deacetylation complex modulates chromatin structure at sites of active transcription to fine-tune gene expression
S Bornelöv, N Reynolds, M Xenophontos, S Gharbi… - Molecular Cell, 2018 - cell.com
Chromatin remodeling complexes play essential roles in metazoan development through
widespread control of gene expression, but the precise molecular mechanisms by which …
widespread control of gene expression, but the precise molecular mechanisms by which …
Beads on a string—nucleosome array arrangements and folding of the chromatin fiber
Understanding how the genome is structurally organized as chromatin is essential for
understanding its function. Here, we review recent developments that allowed the …
understanding its function. Here, we review recent developments that allowed the …