Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action
MA Garcia, J Gil, I Ventoso, S Guerra… - Microbiology and …, 2006 - Am Soc Microbiol
The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …
The dsRNA protein kinase PKR: virus and cell control
The IFN-induced double-stranded RNA-dependent protein kinase (PKR) is one of the four
mammalian serine-threonine kinases (the three others being HRI, GCN2 and PERK) that …
mammalian serine-threonine kinases (the three others being HRI, GCN2 and PERK) that …
Poxvirus pathogenesis
RM Buller, GJ Palumbo - Microbiological reviews, 1991 - Am Soc Microbiol
Poxviruses are a highly successful family of pathogens, with variola virus, the causative
agent of smallpox, being the most notable member. Poxviruses are unique among animal …
agent of smallpox, being the most notable member. Poxviruses are unique among animal …
The integrated stress response and phosphorylated eukaryotic initiation factor 2α in neurodegeneration
S Bond, C Lopez-Lloreda, PJ Gannon… - … of Neuropathology & …, 2020 - academic.oup.com
The proposed molecular mechanisms underlying neurodegenerative pathogenesis are
varied, precluding the development of effective therapies for these increasingly prevalent …
varied, precluding the development of effective therapies for these increasingly prevalent …
Avian interferons and their antiviral effectors
D Santhakumar, D Rubbenstroth… - Frontiers in …, 2017 - frontiersin.org
Interferon (IFN) responses, mediated by a myriad of IFN-stimulated genes (ISGs), are the
most profound innate immune responses against viruses. Cumulatively, these IFN effectors …
most profound innate immune responses against viruses. Cumulatively, these IFN effectors …
Interferon-induced proteins and the antiviral state
P Staeheli - Advances in virus research, 1990 - Elsevier
Publisher Summary This chapter reviews recent work on the best-characterized interferon
(IFN)-induced proteins. The focus is on IFN-induced proteins with assigned functions …
(IFN)-induced proteins. The focus is on IFN-induced proteins with assigned functions …
The human 2′-5′ oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2′-5′ instead of 3′-5′ phosphodiester bond formation
AG Hovanessian, J Justesen - Biochimie, 2007 - Elsevier
The demonstration by Kerr and colleagues that double-stranded (ds) RNA inhibits drastically
protein synthesis in cell-free systems prepared from interferon-treated cells, suggested the …
protein synthesis in cell-free systems prepared from interferon-treated cells, suggested the …
[图书][B] The interferon system
WE Stewart II - 2012 - books.google.com
This book is an update of Interferon, published in 1969 by Dr. Jan Vilcek. The field of
interferon research has since expanded from its former narrow treatment of interferon strictly …
interferon research has since expanded from its former narrow treatment of interferon strictly …
PKR transduces MDA5-dependent signals for type I IFN induction
AM Pham, FG Santa Maria, T Lahiri, E Friedman… - PLoS …, 2016 - journals.plos.org
Sensing invading pathogens early in infection is critical for establishing host defense. Two
cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) …
cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) …
On the discovery of interferon-inducible, double-stranded RNA activated enzymes: the 2′–5′ oligoadenylate synthetases and the protein kinase PKR
AG Hovanessian - Cytokine & growth factor reviews, 2007 - Elsevier
The demonstration that double-stranded (ds) RNA inhibits protein synthesis in cell-free
systems prepared from interferon-treated cells, lead to the discovery of the two interferon …
systems prepared from interferon-treated cells, lead to the discovery of the two interferon …