The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Significant effort has been devoted to discovering microRNA (miRNA) disease biomarkers.
In particular, miRNAs in whole blood or specific blood components are candidates for …

While the number of human miRNA candidates continuously increases, only a few of them
are completely characterized and experimentally validated. Toward determining the total …

Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20–23-nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …

Diabetes mellitus is characterized by insulin secretion from pancreatic β cells that is
insufficient to maintain blood glucose homeostasis. Autoimmune destruction of β cells …

Background Alzheimer disease (AD) is the most common form of dementia but the
identification of reliable, early and non-invasive biomarkers remains a major challenge. We …

Traditional molecular beacons, widely applied for detection of nucleic acids, have an
intrinsic limitation on sensitivity, as one target molecule converts only one beacon molecule …

microRNAs (miRNAs) are a class of small non-coding endogenous RNA molecules that
regulate a wide range of biological processes by post-transcriptionally regulating gene …

BACKGROUND Genomic studies have yielded important insights into the pathogenesis of
obesity. Circulating microRNAs (miRNAs) are valuable biomarkers of systemic diseases and …

Importance The overall low survival rate of patients with lung cancer calls for improved
detection tools to enable better treatment options and improved patient outcomes …