Enterobacteriaceae are a large family of Gram-negative, non-spore-forming bacteria.
Although many species exist as part of the natural flora of animals including humans, some …

The laboratory mouse is an artificial construct with a complex relationship to its natural
ancestors. In 2002, the mouse became the first mammalian model organism with a reference …

Natural variation for LPS‐induced lethal inflammation in mice is useful for identifying new
genes that regulate sepsis, which could form the basis for novel therapies for systemic …

Unblocked fleas can transmit Yersinia pestis, the bacterium that causes plague, shortly (≤ 4
d) after taking an infectious bloodmeal. Investigators have measured so-called early-phase …

Cellular senescence is a program of cell cycle arrest, apoptosis resistance, and cytokine
release induced by stress exposure in metazoan cells. Landmark studies in laboratory mice …

Background Susceptibility to infection is in part genetically driven, and C57BL/6 mice resist
various pathogens through the proinflammatory response of their M1 macrophages (MPs) …

Background. Although laboratory mice are usually highly susceptible to Yersinia pestis, we
recently identified a mouse strain (SEG) that exhibited an exceptional capacity to resist …

The Gram negative bacterium Yersinia pestis can infect humans by multiple routes to cause
plague. Three plague pandemics have occurred and Y. pestis has been linked to biowarfare …

The great gerbil (Rhombomys opimus) is a social rodent living in permanent, complex
burrow systems distributed throughout Central Asia, where it serves as the main host of …

Pathogens can elicit high selective pressure on hosts, potentially altering genetic diversity
over short evolutionary timescales. Intraspecific variation in immune response is observable …