Most cancers arise in individuals over the age of 60. As the world population is living longer
and reaching older ages, cancer is becoming a substantial public health problem. It is …

Tumors strongly depend on their surrounding tumor microenvironment (TME) for growth and
progression, since stromal elements are required to generate the optimal conditions for …

Cancer-associated fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis,
cancer cell proliferation, and invasion. We demonstrate that CAFs also mediate tumor …

Prostate cancer (PCa) is one of the most common cancers in European males. Although
therapeutic approaches have changed in recent years, and several new drugs have been …

Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of
cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial …

Benign prostate hyperplasia (BPH) is a major cause of lower urinary tract symptoms, with an
increased volume of transitional zone and associated with increased stromal cells. It is …

Inflammation is now established as a hallmark of cancer. Cancer‐associated fibroblasts
(CAFs) have been established as a key component of the crosstalk between tumour cells …

Fibroblast growth factors (FGFs) are a family of proteins possessing paracrine, autocrine, or
endocrine functions in a variety of biological processes, including embryonic development …

Lower urinary tract symptoms (LUTS)—constituting a spectrum disorder that encompasses
weak stream, nocturia, and sensations of incomplete emptying and intermittent or hesitant …

The human prostate gland is one of the only internal organs that continue to enlarge
throughout adulthood. The specific mechanisms that regulate this growth, as well as the …