Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention

Y Liu, L Li, Z Wang, J Zhang, Z Zhou - Microvascular Research, 2023 - Elsevier
Cardiovascular diseases are one of the leading causes of mortality in developed countries.
Among cardiovascular disorders, myocardial infarction remains a life-threatening problem …

Murine neonatal cardiac B cells promote cardiomyocyte proliferation and heart regeneration

Y Tan, X Duan, B Wang, X Liu, Z Zhan - NPJ Regenerative Medicine, 2023 - nature.com
The irreversible loss of cardiomyocytes in the adult heart following cardiac injury leads to
adverse cardiac remodeling and ventricular dysfunction. However, the role of B cells in …

The secretory leukocyte protease inhibitor (SLPI) in pathophysiology of non-communicable diseases: Evidence from experimental studies to clinical applications

P Mongkolpathumrat, F Pikwong, C Phutiyothin… - Heliyon, 2024 - cell.com
Non-communicable diseases (NCDs) are a worldwide health issue because of their
prevalence, negative impacts on human welfare, and economic costs. Protease enzymes …

Effect of cerium oxide nanoparticles on myocardial cell apoptosis induced by myocardial ischemia-reperfusion injury

Y Zhao, Y Yang, Y Wen, M Zhao… - Cellular and Molecular …, 2022 - cellmolbiol.org
This study was to provide a theoretical basis for effective treatment of myocardial ischemia-
reperfusion injury (I/R injury) and explore the effect of cerium oxide (CeO 2) nanoparticles on …

Adeno-associated virus 9 vector-mediated cardiac-selective expression of human secretory leukocyte protease inhibitor attenuates myocardial ischemia/reperfusion …

P Mongkolpathumrat, N Nernpermpisooth… - Frontiers in …, 2022 - frontiersin.org
Protease enzymes contribute to the initiation of cardiac remodeling and heart failure after
myocardial ischemic/reperfusion (I/R) injury. Protease inhibitors attenuate protease activity …

Anti-protease activity deficient secretory leukocyte protease inhibitor (SLPI) exerts cardioprotective effect against myocardial ischaemia/reperfusion

P Mongkolpathumrat, A Kijtawornrat, E Suwan… - Biomedicines, 2022 - mdpi.com
Inhibition of proteases shows therapeutic potential. Our previous studies demonstrated the
cardioprotection by the Secretory Leukocyte Protease Inhibitor (SLPI) against myocardial …

驱动压导向个体化呼气末正压对机器人辅助前列腺癌根治术老年患者术中脑血流及局部脑氧饱和度的影响.

辛超, 高巨, 葛亚丽, 吴可汀… - Journal of Practical …, 2023 - search.ebscohost.com
目的评价驱动压导向个体化呼吸末正压(PEEP) 通气对机器人辅助前列腺癌根治术(RALP)
老年患者脑血流动力学和局部脑氧饱和度(rSO2) 的影响. 方法择期全麻RALP 老年患者80 例 …

Gelatin-coated silicon oxide nanoparticles encapsulated recombinant human secretory leukocyte protease inhibitor (rhSLPI) reduced cardiac cell death against an in …

F Pikwong, C Phutiyothin, W Chouyratchakarn… - Heliyon, 2023 - cell.com
Abstract Ischemic Heart Disease (IHD) is the main global cause of death. Previous studies
indicated that recombinant human secretory leukocyte protease inhibitor (rhSLPI) exhibits a …

Development of nanoparticles for delivering recombinant human secretory leukocytes protease inhibitor (rhSLPI) for reducing vascular endothelial cell injury

C Phutiyothin, W Chouyratchakarn, F Pikwong… - Materials Today …, 2023 - Elsevier
4. 1. Myocardial ischemia/reperfusion (I/R) is the pathophysiological cause of ischemic heart
disease (IHD), which is a leading cause of death globally. I/R injury impacts and damages …

Development of gelatin-silicon dioxide nanoparticles (GSNPs) encapsulating recombinant human secretory leukocyte protease inhibitor (rhSLPI) for reducing in vitro …

F Pikwong, W Chouyratchakarn, C Phutiyothin… - Materials Today …, 2023 - Elsevier
Abstract Ischemic Heart Disease (IHD) is the main global cause of death. Previous studies
indicate that recombinant human secretory leukocyte protease inhibitor (rhSLPI) exhibits a …