Integrating organoids and organ-on-a-chip devices
Organoids and organs-on-chips are two rapidly emerging 3D cell culture techniques that
aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically …
aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically …
Brain organoid reservoir computing for artificial intelligence
Brain-inspired computing hardware aims to emulate the structure and working principles of
the brain and could be used to address current limitations in artificial intelligence …
the brain and could be used to address current limitations in artificial intelligence …
Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology
Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …
a significant global health challenge as well as a high socioeconomic burden. With aging …
Engineering human brain assembloids by microfluidics
Brain assembloids offer a highly promising strategy to model human brain development and
disease, and advance potential studies in regenerative medicine, therapeutic screening …
disease, and advance potential studies in regenerative medicine, therapeutic screening …
Microfluidics guided by deep learning for cancer immunotherapy screening
Immunocyte infiltration and cytotoxicity play critical roles in both inflammation and
immunotherapy. However, current cancer immunotherapy screening methods overlook the …
immunotherapy. However, current cancer immunotherapy screening methods overlook the …
[HTML][HTML] Engineering human spinal microphysiological systems to model opioid-induced tolerance
Abstract pioids are commonly used for treating chronic pain. However, with continued use,
they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy. The human …
they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy. The human …
Advances in microfluidic technologies in organoid research
Organoids have emerged as major technological breakthroughs and novel organ models
that have revolutionized biomedical research by recapitulating the key structural and …
that have revolutionized biomedical research by recapitulating the key structural and …
[HTML][HTML] Micro/nanosystems for controllable drug delivery to the brain
Drug delivery to the brain is crucial in the treatment for central nervous system disorders.
While significant progress has been made in recent years, there are still major challenges in …
While significant progress has been made in recent years, there are still major challenges in …
Vascularized human brain organoid on-chip
SY Tan, X Feng, LKW Cheng, AR Wu - Lab on a Chip, 2023 - pubs.rsc.org
Modelling the human brain in vitro has been extremely challenging due to the brain's
intricate cellular composition and specific structural architecture. The recent emergence of …
intricate cellular composition and specific structural architecture. The recent emergence of …
Acoustofluidic assembly of primary tumor-derived organotypic cell clusters for rapid evaluation of cancer immunotherapy
Cancer immunotherapy shows promising potential for treating breast cancer. While patients
may have heterogeneous treatment responses for adjuvant therapy, it is challenging to …
may have heterogeneous treatment responses for adjuvant therapy, it is challenging to …