Integrating organoids and organ-on-a-chip devices

Y Zhao, S Landau, S Okhovatian, C Liu… - Nature Reviews …, 2024 - nature.com
Organoids and organs-on-chips are two rapidly emerging 3D cell culture techniques that
aim to bridge the gap between in vitro 2D cultures and animal models to enable clinically …

Brain organoid reservoir computing for artificial intelligence

H Cai, Z Ao, C Tian, Z Wu, H Liu, J Tchieu, M Gu… - Nature …, 2023 - nature.com
Brain-inspired computing hardware aims to emulate the structure and working principles of
the brain and could be used to address current limitations in artificial intelligence …

Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology

FM Pramotton, S Spitz, RD Kamm - Advanced Science, 2024 - Wiley Online Library
Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …

Engineering human brain assembloids by microfluidics

Y Zhu, X Zhang, L Sun, Y Wang, Y Zhao - Advanced materials, 2023 - Wiley Online Library
Brain assembloids offer a highly promising strategy to model human brain development and
disease, and advance potential studies in regenerative medicine, therapeutic screening …

Microfluidics guided by deep learning for cancer immunotherapy screening

Z Ao, H Cai, Z Wu, L Hu, A Nunez… - Proceedings of the …, 2022 - National Acad Sciences
Immunocyte infiltration and cytotoxicity play critical roles in both inflammation and
immunotherapy. However, current cancer immunotherapy screening methods overlook the …

[HTML][HTML] Engineering human spinal microphysiological systems to model opioid-induced tolerance

H Cai, Z Ao, C Tian, Z Wu, C Kaurich, Z Chen, M Gu… - Bioactive Materials, 2023 - Elsevier
Abstract pioids are commonly used for treating chronic pain. However, with continued use,
they may induce tolerance and/or hyperalgesia, which limits therapeutic efficacy. The human …

Advances in microfluidic technologies in organoid research

H Liu, Z Gan, X Qin, Y Wang… - Advanced Healthcare …, 2024 - Wiley Online Library
Organoids have emerged as major technological breakthroughs and novel organ models
that have revolutionized biomedical research by recapitulating the key structural and …

[HTML][HTML] Micro/nanosystems for controllable drug delivery to the brain

M Tian, Z Ma, GZ Yang - The Innovation, 2024 - ncbi.nlm.nih.gov
Drug delivery to the brain is crucial in the treatment for central nervous system disorders.
While significant progress has been made in recent years, there are still major challenges in …

Vascularized human brain organoid on-chip

SY Tan, X Feng, LKW Cheng, AR Wu - Lab on a Chip, 2023 - pubs.rsc.org
Modelling the human brain in vitro has been extremely challenging due to the brain's
intricate cellular composition and specific structural architecture. The recent emergence of …

Acoustofluidic assembly of primary tumor-derived organotypic cell clusters for rapid evaluation of cancer immunotherapy

Z Wu, Z Ao, H Cai, X Li, B Chen, H Tu, Y Wang… - Journal of …, 2023 - Springer
Cancer immunotherapy shows promising potential for treating breast cancer. While patients
may have heterogeneous treatment responses for adjuvant therapy, it is challenging to …