Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral
artery disease continue to be leading causes of death worldwide despite the success of …

Light-field microscopy has emerged as a technique of choice for high-speed volumetric
imaging of fast biological processes. However, artifacts, nonuniform resolution and a slow …

The Zebrafish has emerged to become a powerful vertebrate animal model for
cardiovascular research in recent years. Its advantages include easy genetic manipulation …

This paper reviews the rapid advances that have been made in one form of optical biological
imaging in the last decade, namely that of light sheet microscopy. Although the concept was …

Mechanical force is a determinant of Notch signalling but the mechanism of force detection
and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are …

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal-dominant vascular disorder
characterized by development of high-flow arteriovenous malformations (AVMs) that can …

Blood flow and mechanical forces in the ventricle are implicated in cardiac development and
trabeculation. However, the mechanisms of mechanotransduction remain elusive. This is …

Heart morphogenesis is a complex and dynamic process that has captivated researchers for
almost a century. This process involves three main stages, during which the heart …

Mitochondria are one of the most important organelles in cardiomyocytes. Mitochondrial
homeostasis is necessary for the maintenance of normal heart function. Mitochondria …