Beyond the tail: the consequence of context in histone post-translational modification and chromatin research
EN Weinzapfel, KN Fedder-Semmes… - Biochemical …, 2024 - portlandpress.com
The role of histone post-translational modifications (PTMs) in chromatin structure and
genome function has been the subject of intense debate for more than 60 years. Though …
genome function has been the subject of intense debate for more than 60 years. Though …
Nucleosomal asymmetry: a novel mechanism to regulate nucleosome function
D Valsakumar, P Voigt - Biochemical Society Transactions, 2024 - portlandpress.com
Nucleosomes constitute the fundamental building blocks of chromatin. They are comprised
of DNA wrapped around a histone octamer formed of two copies each of the four core …
of DNA wrapped around a histone octamer formed of two copies each of the four core …
[HTML][HTML] Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein C termini
CL Frazier, D Deb, AM Weeks - bioRxiv, 2024 - ncbi.nlm.nih.gov
In biological systems, ATP provides an energetic driving force for peptide bond formation,
but protein chemists lack tools that emulate this strategy. Inspired by the eukaryotic …
but protein chemists lack tools that emulate this strategy. Inspired by the eukaryotic …