Endothelial dysfunction represents a key mechanism underlying heart failure with preserved
ejection fraction (HFpEF), diabetes mellitus (DM), and frailty. However, reliable biomarkers …

Background To identify regulatory ncRNA molecules that can cause differential expression
of CDH2 in intervertebral disc degeneration (IDD) and explore whether there are other ways …

We studied the effects of betaine on steroidogenesis, endoplasmic reticulum stress and Nrf2
antioxidant pathways of mice Leydig cells under hyperglycaemia conditions. Leydig cells …

Diabetic testicular damage is quite a common and significant complication in diabetic men,
which could result in infertility. The natural fertility rate of type 1 diabetes men is only 50 …

Leydig cells produce hormones required for the development and maintenance of sex
characteristics and fertility in males. MEF2 transcription factors are important regulators of …

As a serotonin antagonist, tropisetron positively affects blood glucose lowering, insulin
synthesis, pancreas inflammation, and apoptosis in diabetes. Reproductive disorders are …

In this study, we detected the expression of mRNAs, lncRNAs, and miRNAs in primary
cultured leydig cells (LCs) and sertoli cells (SCs) of yak by RNA sequencing technology. A …

Background. Our previous works revealed Yangjing capsule (YC) could inhibit cell
apoptosis and promote testosterone production in Leydig cells. SET protein has been …

Background: The aim of this study was to evaluate the prevalence of DM among patients
with ED and the impact of glycometabolic compensation and antihyperglycemic treatment on …

Diabetes is linked to male infertility, but the mechanisms and therapeutic options remain
unclear. This study investigates the effects of semaglutide on testicular function in a diabetes …