Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

Many essential biological processes including cell regulation and signalling are mediated
through the assembly of protein complexes. Changes to protein-protein interaction (PPI) …

Cellular functions are governed by molecular machines that assemble through protein-
protein interactions. Their atomic details are critical to studying their molecular mechanisms …

Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan …

Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced
algorithms to identify drivers now exist, but systematic attempts to combine and optimize …

The protein structure field is experiencing a revolution. From the increased throughput of
techniques to determine experimental structures, to developments such as cryo-EM that …

Technological and computational advances in genomics and interactomics have made it
possible to identify how disease mutations perturb protein–protein interaction (PPI) networks …

Many mutations in cancer are of unknown functional significance. Standard methods use
statistically significant recurrence of mutations in tumor samples as an indicator of functional …

The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly
understood due to limited samples or targeted genes in current studies. Here, we perform …

Transcriptional dysregulation induced by aberrant transcription factors (TF) is a key feature
of cancer, but its global influence on drug sensitivity has not been examined. Here, we infer …