In the heart, adrenergic stimulation activates the β-adrenergic receptors coupled to the
heterotrimeric stimulatory Gs protein, followed by subsequent activation of adenylyl cyclase …

Blood pressure is determined by cardiac output and peripheral vascular resistance. The L-
type voltage-gated Ca2+ (Cav1. 2) channel in small arteries and arterioles plays an …

Rationale: Familial sinus node and atrioventricular conduction dysfunction is a rare disorder
that leads to paroxysmal dizziness, fatigue, and syncope because of a temporarily or …

A novel neuropeptide spexin was found to be broadly expressed in various endocrine and
nervous tissues while little is known about its functions. This study investigated the role of …

Rationale: Antral peristalsis is responsible for gastric emptying. Its failure is called
gastroparesis and often caused by dysfunction of enteric neurons and interstitial cells of …

Cav1. 2 plays an essential role in learning and memory, drug addiction, and neuronal
development. Intracellular calcium homeostasis is disrupted in neurodegenerative diseases …

Oxytocin is a neuropeptide that plays important peripheral and central neuromodulatory
functions. Our data show that, following activation of oxytocin receptors (OtRs) with the …

L-type voltage-gated CaV1. 2 channels crucially regulate cardiac muscle contraction.
Activation of β-adrenergic receptors (β-AR) augments contraction via protein kinase A (PKA) …

Voltage-gated calcium channels are the major pathway for Ca 2+ influx to initiate the
contraction of smooth and cardiac muscles. Alterations of calcium channel function have …

ABSTRACT L-type-voltage-dependent Ca2+ channels (L-VDCCs; CaV1. 2, α1C), crucial in
cardiovascular physiology and pathology, are modulated via activation of G-protein-coupled …