Neurotoxicity in snakebite—the limits of our knowledge

UK Ranawaka, DG Lalloo… - PLoS neglected tropical …, 2013 - journals.plos.org
Snakebite is classified by the WHO as a neglected tropical disease. Envenoming is a
significant public health problem in tropical and subtropical regions. Neurotoxicity is a key …

Secreted Phospholipases A2 of Snake Venoms: Effects on the Peripheral Neuromuscular System with Comments on the Role of Phospholipases A2 in Disorders of …

JB Harris, T Scott-Davey - Toxins, 2013 - mdpi.com
Neuro-and myotoxicological signs and symptoms are significant clinical features of
envenoming snakebites in many parts of the world. The toxins primarily responsible for the …

The deep origin and recent loss of venom toxin genes in rattlesnakes

NL Dowell, MW Giorgianni, VA Kassner, JE Selegue… - Current Biology, 2016 - cell.com
The genetic origin of novel traits is a central but challenging puzzle in evolutionary biology.
Among snakes, phospholipase A2 (PLA 2)-related toxins have evolved in different lineages …

Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management

J Boldrini-França, C Corrêa-Netto, MMS Silva… - Journal of …, 2010 - Elsevier
We report the comparative proteomic and antivenomic characterization of the venoms of
subspecies cascavella and collilineatus of the Brazilian tropical rattlesnake Crotalus …

Snake Venom PLA2, a Promising Target for Broad‐Spectrum Antivenom Drug Development

H Xiao, H Pan, K Liao, M Yang… - BioMed research …, 2017 - Wiley Online Library
Snakebite envenomation is a neglected global health problem, causing substantial mortality,
disability, and psychological morbidity, especially in rural tropical and subtropical zones …

Venom variability and envenoming severity outcomes of the Crotalus scutulatus scutulatus (Mojave rattlesnake) from Southern Arizona

DJ Massey, JJ Calvete, EE Sánchez, L Sanz… - Journal of …, 2012 - Elsevier
Twenty-one Mojave rattlesnakes, Crotalus scutulatus scutulatus (C. s. scutulatus), were
collected from Arizona and New Mexico USA Venom proteome of each specimen was …

Synergistic strategies of predominant toxins in snake venoms

S Xiong, C Huang - Toxicology letters, 2018 - Elsevier
Synergism is a significant phenomenon present in snake venoms that may be an evolving
strategy to potentiate toxicities. Synergism exists between different toxins or toxin complexes …

[PDF][PDF] Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?

B Lomonte, JM Gutiérrez - 2011 - researchgate.net
Abstract Phospholipases A2 (PLA2s) are abundant components in snake venoms, which
play important toxic roles. This review focuses on group II PLA2s endowed with myotoxic …

Coralsnake venomics: analyses of venom gland transcriptomes and proteomes of six Brazilian taxa

SD Aird, NJ da Silva Jr, L Qiu, A Villar-Briones… - Toxins, 2017 - mdpi.com
Venom gland transcriptomes and proteomes of six Micrurus taxa (M. corallinus, M.
lemniscatus carvalhoi, M. lemniscatus lemniscatus, M. paraensis, M. spixii spixii, and M …

Crystal structure of crotoxin reveals key residues involved in the stability and toxicity of this potent heterodimeric β-neurotoxin

G Faure, H Xu, FA Saul - Journal of molecular biology, 2011 - Elsevier
The crystal structure of crotoxin, a potent presynaptic neurotoxin from Crotalus
durissusterrificus, was solved at 1.35 Å resolution. It shows the architecture of the three …