Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

Regulation of immune function continues to be one of the most well recognized extraskeletal
actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells …

Vitamin D and its active metabolites are important nutrients for human skeletal health. UV
irradiation of skin converts 7-dehydrocholesterol into vitamin D3, which metabolized in the …

The active form of vitamin D 3, 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), is primarily
known as a key regulator of calcium and phosphate homeostasis. It exerts its biological …

Despite an increase in the incidence of breast cancer worldwide, overall prognosis has
been consistently improving owing to the development of multiple targeted therapies and …

Ageing can occur at different rates, but what controls this variable rate is unknown. Here I
have developed a hypothesis that vitamin D may act to control the rate of ageing. The basis …

Tumor cells along with a small proportion of cancer stem cells exist in a stromal
microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells …

Vitamin D deficiency has been clearly linked to major chronic diseases associated with
oxidative stress, inflammation, and aging, including cardiovascular and neurodegenerative …

Vitamin D regulates the pleiotropic effect to maintain cellular homeostasis and
epidemiological evidence establishes an association between vitamin D deficiency and …