Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …

Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Studies show that the autonomic nervous system (ANS) has an important impact on health in
general. In response to environmental demands, homeostatic processes are often …

Coronary artery disease (CAD) is a multifactorial disease with a high prevalence, particularly
in developing countries. Currently, the investigation of telomeres as a potential tool for the …

Mutations in the promoter of human telomerase reverse transcriptase (hTERT) result in
hyperactivation of hTERT. Notably, all mutations are G> A transitions, frequently found in a …

Maintenance of chromosomal telomere length is a hallmark of cancer cells and a
prerequisite for stemness. In 85–90% of all human cancers, telomere length maintenance is …

Chronic stress is associated with the accelerated aging of the immune system and
represents a potent risk factor for the development and progression of a wide range of …

Background hTERT gene plays an important role in melanoma, although the specific
mechanism involved is unclear. The aim of this study was to screen and identify the relative …

Telomeres are specialised structures at the end of linear chromosomes. They consist of
tandem repeats of the hexanucleotide sequence TTAGGG, as well as a protein complex …

Simple Summary Maintenance of telomeres is a fundamental step in human carcinogenesis
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …