Onycholysis–the separation of the nail plate from the nail bed occurs in fingers and toenails.
It is diagnosed by the whitish appearance of the separated nail plate from the nail bed. In …

When dealing with nails, pathologic examination is often indispensable to reach an accurate
diagnosis. This requires a biopsy correctly performed by the dermatologist, a specimen …

The tips of the digits of some mammals, including human infants and mice, are capable of
complete regeneration after injury. This process is reliant on the presence of the overlaying …

This chapter provides the scientific backdrop to the interpretation and understanding of
many diseases of the nails and their management. Embryogenesis represents the original …

The nail unit and hair follicle are both hard keratin-producing organs that share various
biological features. In this study, we used digital spatial profiling and single-cell RNA …

■ Abstract The nail unit is the largest and a rather complex skin appendage. It is located on
the dorsal aspect of the tips of fingers and toes and has important protective and sensory …

Research on human nail tissue has been limited by the restricted access to fresh specimen.
Here, we studied transcriptome profiles of human nail units using polydactyly specimens …

Background The lack of highly specific clinical and histopathological criteria has contributed
to the delay in diagnosis of subungual melanoma in situ in its early stages. Methods …

This comprehensive review of the histopathology of the human nail will act as a masterclass
for all dermatologists, dermatopathologists, and nail-interested pathologists who have to …

Subungual melanoma is a rare subtype of melanoma that usually originates and spreads
from the nail matrix. Because of its poor prognosis and short matrix-to-bone distance …