Quinoline drug–heme interactions and implications for antimalarial cytostatic versus cytocidal activities
Historically, the most successful molecular target for antimalarial drugs has been heme
biomineralization within the malarial parasite digestive vacuole. Heme released from …
biomineralization within the malarial parasite digestive vacuole. Heme released from …
Heme and blood-feeding parasites: friends or foes?
Hemoparasites, like malaria and schistosomes, are constantly faced with the challenges of
storing and detoxifying large quantities of heme, released from their catabolism of host …
storing and detoxifying large quantities of heme, released from their catabolism of host …
Antimalarial quinoline drugs inhibit β-hematin and increase free hemin catalyzing peroxidative reactions and inhibition of cysteine proteases
Malaria caused by Plasmodium affects millions people worldwide. Plasmodium consumes
hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …
hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …
An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum
M Asad, Y Yamaryo-Botté, ME Hossain, V Thakur… - BMC biology, 2021 - Springer
Background Plasmodium falciparum is the pathogen responsible for the most devastating
form of human malaria. As it replicates asexually in the erythrocytes of its human host, the …
form of human malaria. As it replicates asexually in the erythrocytes of its human host, the …
Composition, antioxidant and chemotherapeutic properties of the essential oils from two Origanum species growing in Pakistan
The GC-MS analyses of Origanum majorana L.(OME) and Origanum vulgare L.(OVE),
Lamiaceae, essential oils helped identification of 39 (96.4% of the total oils) and 43 (92.9 …
Lamiaceae, essential oils helped identification of 39 (96.4% of the total oils) and 43 (92.9 …
[HTML][HTML] Hemoglobin degradation in malaria-infected erythrocytes determined from live cell magnetophoresis
LR Moore, H Fujioka, PS Williams… - … : official publication of …, 2006 - ncbi.nlm.nih.gov
During intra-erythrocytic development, malaria trophozoites digest hemoglobin, which leads
to parasite growth and asexual replication while accumulating toxic heme. To avoid death …
to parasite growth and asexual replication while accumulating toxic heme. To avoid death …
Malaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice
Heme-biosynthetic pathway of malaria parasite is dispensable for asexual stages, but
essential for mosquito and liver stages. Despite having backup mechanisms to acquire …
essential for mosquito and liver stages. Despite having backup mechanisms to acquire …
Microwaves can kill malaria parasites non-thermally
LM Coronado, JA Stoute, CT Nadovich… - Frontiers in Cellular …, 2023 - frontiersin.org
Malaria, which infected more than 240 million people and killed around six hundred
thousand only in 2021, has reclaimed territory after the SARS-CoV-2 pandemic. Together …
thousand only in 2021, has reclaimed territory after the SARS-CoV-2 pandemic. Together …
A near-infrared “matchbox size” spectrometer to detect and quantify malaria parasitemia
JA Adegoke, K Kochan, P Heraud… - Analytical …, 2021 - ACS Publications
New point-of-care diagnostic approaches for malaria that are sensitive to low parasitemia,
easy to use in a field setting, and affordable are urgently required to meet the World Health …
easy to use in a field setting, and affordable are urgently required to meet the World Health …
Curcumin-Arteether Combination Therapy of Plasmodium berghei-Infected Mice Prevents Recrudescence Through Immunomodulation
Earlier studies in this laboratory have shown the potential of artemisinin-curcumin
combination therapy in experimental malaria. In a parasite recrudescence model in mice …
combination therapy in experimental malaria. In a parasite recrudescence model in mice …