T regulatory cells suppress a variety of immune responses to self-antigens and play a role in
peripheral tolerance maintenance by limiting autoimmune disorders, and other pathological …

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …

IL-1β is a proinflammatory mediator with roles in innate and adaptive immunity. Here we
show that IL-1β contributes to autoimmune arthritis by inducing osteoclastogenic capacity in …

The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …

The immunosuppressive function of regulatory T (Treg) cells is dependent on continuous
expression of the transcription factor Foxp3. Foxp3 loss of function or induced ablation of …

The ability of regulatory T (Treg) cells to control the immune response and limit the
development of autoimmune diseases is determined by distinct molecular processes, which …

Chronic rhinosinusitis (CRS) is a chronic inflammatory condition of the nasal and paranasal
sinus mucosa that affects up to 10% of the population worldwide. CRS is the most …

The molecular programs involved in regulatory T (Treg) cell activation and homeostasis
remain incompletely understood. Here, we show that T cell receptor (TCR) signaling in Treg …

Gut microbiota stimulate and shape the body's adaptive immune response through bacterial
components and its active metabolites, which orchestrates the formation and maintenance of …