Development makes reiterative use of a surprisingly small set of essential molecular signals:
the Wingless (Wg/Wnt), Hedgehog (Hh), Transforming Growth Factor-(TGF-), Receptor …

The Ras and Notch signaling pathways are used over and over again during development
to control many different biological processes. Frequently, these two signaling pathways …

RBP-J is a key mediator of Notch signaling that regulates a large spectrum of cell fate
determinations. To elucidate the functions of Notch signaling in T cell development, we …

Cell–cell signaling mediated by Notch is critical during many different developmental
processes for the specification or restriction of cell fates. Currently, the only known …

Notch receptors participate in a conserved signaling pathway that controls the development
of diverse tissues and cell types, including lymphoid cells. Signaling is normally initiated …

Notch signal transduction regulates expression of downstream genes through the activation
of the DNA-binding protein Su (H)/CBF1. In Drosophila most of Notch signaling requires Su …

In the developing central nervous system (CNS), Notch signaling preserves progenitor pools
and inhibits neurogenesis and oligodendroglial differentiation. It has recently been …

The importance of lateral inhibition mediated by NOTCH signaling is well demonstrated to
control neurogenesis both in invertebrates and vertebrates. We have identified the chicken …

Intercellular signaling through the cell-surface receptor Notch plays important roles in a
variety of developmental processes as well as in pathogenesis of some human cancers and …

Notch (N) signaling is an evolutionarily conserved mechanism that regulates many cell-fate
decisions. deltex (dx) encodes an E3-ubiquitin ligase that binds to the intracellular domain of …