[HTML][HTML] Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

M Jakaria, S Azam, ME Haque, SH Jo, MS Uddin… - Redox biology, 2019 - Elsevier
Taurine is a sulfur-containing amino acid and known as semi-essential in mammals and is
produced chiefly by the liver and kidney. It presents in different organs, including retina …

Taurine as a natural antioxidant: From direct antioxidant effects to protective action in various toxicological models

PF Surai, K Earle-Payne, MT Kidd - Antioxidants, 2021 - mdpi.com
Natural antioxidants have received tremendous attention over the last 3 decades. At the
same time, the attitude to free radicals is slowly changing, and their signalling role in …

Realistic expectations of prepulse inhibition in translational models for schizophrenia research

NR Swerdlow, M Weber, Y Qu, GA Light, DL Braff - Psychopharmacology, 2008 - Springer
Introduction Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the
startling effects of a subsequent intense abrupt stimulus. This startle-inhibiting effect of the …

Is taurine a functional nutrient?

T Bouckenooghe, C Remacle… - Current Opinion in …, 2006 - journals.lww.com
Taurine appears to have multiple functions and plays an important role in many
physiological processes, such as osmoregulation, immunomodulation and bile salt …

Versatile triad alliance: bile acid, taurine and microbiota

K Duszka - Cells, 2022 - mdpi.com
Taurine is the most abundant free amino acid in the body, and is mainly derived from the
diet, but can also be produced endogenously from cysteine. It plays multiple essential roles …

Oxidative damage in Huntington's disease pathogenesis

SE Browne, MF Beal - Antioxidants & redox signaling, 2006 - liebertpub.com
Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the
progressive development of involuntary choreiform movements, cognitive impairment …

Taurine and central nervous system disorders

J Menzie, C Pan, H Prentice, JY Wu - Amino acids, 2014 - Springer
In the present era, investigators seek to find therapeutic interventions that are multifaceted in
their mode of action. Such targets provide the most advantageous routes for addressing the …

Insights into GABAAergic system alteration in Huntington's disease

YT Hsu, YG Chang, Y Chern - Royal Society Open …, 2018 - royalsocietypublishing.org
Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disease that is characterized by a triad of motor, psychiatric and cognitive impairments …

[PDF][PDF] Integrative characterization of the R6/2 mouse model of Huntington's disease reveals dysfunctional astrocyte metabolism

NH Skotte, JV Andersen, A Santos, BI Aldana… - Cell Reports, 2018 - cell.com
Huntington's disease is a fatal neurodegenerative disease, where dysfunction and loss of
striatal and cortical neurons are central to the pathogenesis of the disease. Here, we …

Prospects for cannabinoid therapies in basal ganglia disorders

J Fernández‐Ruiz, M Moreno‐Martet… - British journal of …, 2011 - Wiley Online Library
Cannabinoids are promising medicines to slow down disease progression in
neurodegenerative disorders including Parkinson's disease (PD) and Huntington's disease …