Corneal Endothelial-like Cells Derived from Induced Pluripotent Stem Cells for Cell Therapy

XY Ng, GSL Peh, GHF Yam, HG Tay… - International Journal of …, 2023 - mdpi.com
Corneal endothelial dysfunction is one of the leading causes of corneal blindness, and the
current conventional treatment option is corneal transplantation using a cadaveric donor …

Exploring Single-cell RNA sequencing as a decision-making tool in the clinical management of Fuchs' Endothelial Corneal Dystrophy

GN Yang, YBY Sun, PK Roberts, H Moka… - Progress in Retinal and …, 2024 - Elsevier
Single-cell RNA sequencing (scRNA-seq) has enabled the identification of novel gene
signatures and cell heterogeneity in numerous tissues and diseases. Here we review the …

Molecular and cellular mechanisms of corneal scarring and advances in therapy

M Fuest, V Jhanji, GHF Yam - International Journal of Molecular Sciences, 2023 - mdpi.com
On the basis of WHO global blindness data, it may be stated that 23 million people globally
suffer from unilateral corneal blindness, while 4.9 million are bilaterally blind [1]. Corneal …

Emerging alternatives to keratoplasty for corneal endothelial cell dysfunction

R Kaufman, AS Jun - Current Opinion in Ophthalmology, 2024 - journals.lww.com
A plethora of innovative alternatives to keratoplasty for endothelial disease is in
development. Among these, surgical methods are still the mainstay of treatment and closest …