The cancer–natural killer cell immunity cycle

ND Huntington, J Cursons, J Rautela - Nature Reviews Cancer, 2020 - nature.com
Immunotherapy with checkpoint blockade induces rapid and durable immune control of
cancer in some patients and has driven a monumental shift in cancer treatment. Neoantigen …

[HTML][HTML] Natural killer cells: In health and disease

A Mandal, C Viswanathan - Hematology/oncology and stem cell therapy, 2015 - Elsevier
Natural killer (NK) cells constitute our bodies' frontline defense system, guarding against
tumors and launching attacks against infections. The activities of NK cells are regulated by …

Functions of natural killer cells

E Vivier, E Tomasello, M Baratin, T Walzer… - Nature …, 2008 - nature.com
Natural killer (NK) cells are effector lymphocytes of the innate immune system that control
several types of tumors and microbial infections by limiting their spread and subsequent …

[HTML][HTML] Natural killer cells in SARS-CoV-2 infection: pathophysiology and therapeutic implications

C Di Vito, F Calcaterra, N Coianiz, S Terzoli… - Frontiers in …, 2022 - frontiersin.org
Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …

The role of microglia and macrophages in CNS homeostasis, autoimmunity, and cancer

J Yin, KL Valin, ML Dixon… - Journal of immunology …, 2017 - Wiley Online Library
Macrophages are major cell types of the immune system, and they comprise both tissue‐
resident populations and circulating monocyte‐derived subsets. Here, we discuss microglia …

NK cells and cancer immunosurveillance

I Waldhauer, A Steinle - Oncogene, 2008 - nature.com
Natural killer (NK) cells are lymphocytes of the innate immune system that monitor cell
surfaces of autologous cells for an aberrant expression of MHC class I molecules and cell …

Formation and function of the lytic NK-cell immunological synapse

JS Orange - Nature Reviews Immunology, 2008 - nature.com
The natural killer (NK)-cell immunological synapse is the dynamic interface formed between
an NK cell and its target cell. Formation of the NK-cell immunological synapse involves …

Effect of NKG2D ligand expression on host immune responses

M Champsaur, LL Lanier - Immunological reviews, 2010 - Wiley Online Library
Natural killer group 2, member D (NKG2D) is an activating receptor present on the surface of
natural killer (NK) cells, some NKT cells, CD8+ cytotoxic T cells, γδ T cells, and under certain …

Human liver-resident CD56bright/CD16neg NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways

K Hudspeth, M Donadon, M Cimino, E Pontarini… - Journal of …, 2016 - Elsevier
Rationale The liver-specific natural killer (NK) cell population is critical for local innate
immune responses, but the mechanisms that lead to their selective homing and the …

Evidence for immune cell involvement in decidual spiral arteriole remodeling in early human pregnancy

SD Smith, CE Dunk, JD Aplin, LK Harris… - The American journal of …, 2009 - Elsevier
Decidual artery remodeling is essential for a healthy pregnancy. This process involves loss
of vascular smooth muscle cells and endothelium, which are replaced by endovascular …