Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

Stroke is a major cause of death and adult disability. However, therapeutic options remain
limited. Numerous pathways underlie acute responses of brain tissue to stroke. Early events …

Ischemic stroke is a main cause of cognitive neurological deficits and disability worldwide
due to a plethora of neuronal apoptosis. Unfortunately, numerous neuroprotectants for …

Stroke occurs when a cerebral blood vessel is blocked or ruptured, and it is the major cause
of death and adult disability worldwide. Various pharmacological agents have been …

Erythropoietin (EPO) is a cytokine mainly induced in hypoxia conditions. Its major production
site is the kidney. EPO primarily acts on the erythroid progenitor cells in the bone marrow …

Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs
through over-stimulation of glutamate receptors, specifically NMDAR, while in the non …

The cerebral ischemic reperfusion injury may leads to morbidity and mortality in patients.
phosphatidylinositol 3-kinase (PI3K) signaling pathway has been believed to work in …

Cytokines control immune-related events and are critically involved in a plethora of
physiological and pathophysiological processes including autoimmunity and cancer …

Neuron-glia interactions are essential for the central nervous system's homeostasis.
Microglial cells are one of the key support cells in the brain that respond to disruptions in …

Stroke is a debilitating disease and has the ability to culminate in devastating clinical
outcomes. Ischemic stroke followed by reperfusion entrains cerebral ischemia/reperfusion …