Diabetes is the result of having inadequate supply of functional insulin-producing β cells.
Two possible approaches for replenishing the β cells are:(1) replacement by transplanting …

Stem cells are unique cell populations with the ability to undergo both self-renewal and
differentiation. A wide variety of adult mammalian tissues harbors stem cells, yet “adult” stem …

Adult mitotic tissues like the intestine, skin, and blood undergo constant turnover throughout
the life of an organism. Knowing the identity of the stem cell is crucial to understanding …

It has generally proven challenging to produce functional β cells in vitro. Here, we describe a
previously unidentified protein C receptor positive (Procr+) cell population in adult mouse …

The location and lineage of cells that give rise to endocrine islets during embryogenesis has
not been established nor has the origin or identity of adult islet stem cells. We have …

Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt‐agonistic R‐
spondins (RSPOs). Intestinal, stomach and liver Lgr5+ stem cells grow in 3D cultures to form …

Amniotic epithelial cells develop from the epiblast by 8 days after fertilization and before
gastrulation, opening the possibility that they might maintain the plasticity of pregastrulation …

Although the source of embryonic stem (ES) cells presents ethical concerns, their use may
lead to many clinical benefits if differentiated cell types can be derived from them and used …

Novel strategies in diabetes therapy would obviously benefit from the use of beta (β) cell
stem/progenitor cells. However, whether or not adult β cell progenitors exist is one of the …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …