Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy

B Toledo, L Zhu Chen, M Paniagua-Sancho… - Journal of hematology & …, 2024 - Springer
Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours
are known as tumour-associated macrophages (TAMs). These specialized immune cells …

Tumor-associated macrophages: An effective player of the tumor microenvironment

U Basak, T Sarkar, S Mukherjee… - Frontiers in …, 2023 - frontiersin.org
Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …

Pre-metastatic niche: formation, characteristics and therapeutic implication

Y Wang, J Jia, F Wang, Y Fang, Y Yang… - … and Targeted Therapy, 2024 - nature.com
Distant metastasis is a primary cause of mortality and contributes to poor surgical outcomes
in cancer patients. Before the development of organ-specific metastasis, the formation of a …

Decoding the spatiotemporal heterogeneity of tumor-associated macrophages

X Chu, Y Tian, C Lv - Molecular Cancer, 2024 - Springer
Tumor-associated macrophages (TAMs) are pivotal in cancer progression, influencing tumor
growth, angiogenesis, and immune evasion. This review explores the spatial and temporal …

HEARTSVG: a fast and accurate method for identifying spatially variable genes in large-scale spatial transcriptomics

X Yuan, Y Ma, R Gao, S Cui, Y Wang, B Fa… - Nature …, 2024 - nature.com
Identifying spatially variable genes (SVGs) is crucial for understanding the spatiotemporal
characteristics of diseases and tissue structures, posing a distinctive challenge in spatial …

Cuproptosis and cuproptosis-related genes: Emerging potential therapeutic targets in breast cancer

X Liu, B Luo, X Wu, Z Tang - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Breast cancer is one of the most common malignant tumors in women worldwide, and thus, it
is important to enhance its treatment efficacy [1]. Copper has emerged as a critical trace …

Tumor associated macrophages in breast cancer progression: implications and clinical relevance

M Stavrou, A Constantinidou - Frontiers in Immunology, 2024 - frontiersin.org
Macrophages represent an immune cell population characterized by high plasticity and a
range of properties and functions. Their activation status and specific phenotype are highly …

SHISA3 Reprograms Tumor‐Associated Macrophages Toward an Antitumoral Phenotype and Enhances Cancer Immunotherapy

S Zhang, B Yu, C Sheng, C Yao, Y Liu… - Advanced …, 2024 - Wiley Online Library
The main challenge for immune checkpoint blockade (ICB) therapy lies in
immunosuppressive tumor microenvironment (TME). Repolarizing M2‐like tumor …

Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs

S Shao, H Miao, W Ma - Frontiers in Immunology, 2023 - frontiersin.org
Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME),
influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit …

[HTML][HTML] Advances in melanoma: from genetic insights to therapeutic innovations

F Valdez-Salazar, LA Jiménez-Del Rio… - Biomedicines, 2024 - mdpi.com
Advances in melanoma research have unveiled critical insights into its genetic and
molecular landscape, leading to significant therapeutic innovations. This review explores the …