Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Mitochondria are organelles with a highly dynamic ultrastructure maintained by a delicate
equilibrium between its fission and fusion rates. Understanding the factors influencing this …

It is well documented that the rate of aging can be slowed, but it remains unclear to which
extent aging-associated conditions can be reversed. How the interface of immunity and …

Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-
accumulation of ROS causes premature aging and/or death and is associated with various …

Mammals have several organs comprising various cells with different functions.
Furthermore, eukaryotic cells are compartmentalized into functionally distinct organelles …

Some of the most challenging stress conditions that organisms encounter during their
lifetime involve the transient accumulation of reactive oxygen and chlorine species …

The ketone body β-hydroxybutyrate is no longer viewed simply as a metabolic intermediate,
as it regulates a broad range of physiological processes at cellular and systemic levels …

It is widely reported that the mitochondrial membrane potential,∆ Ψm, is reduced in aging
animals. It was recently suggested that the lower∆ Ψm in aged animals modulates …

Sirtuins, initially described as histone deacetylases and gene silencers in yeast, are now
known to have many more functions and to be much more abundant in living organisms. The …

The global concept of oxidative stress is defined as “an imbalance between oxidants and
antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control …