[HTML][HTML] Coronavirus genomic RNA packaging

PS Masters - Virology, 2019 - Elsevier
RNA viruses carry out selective packaging of their genomes in a variety of ways, many
involving a genomic packaging signal. The first coronavirus packaging signal was …

The structure and functions of coronavirus genomic 3′ and 5′ ends

D Yang, JL Leibowitz - Virus research, 2015 - Elsevier
Coronaviruses (CoVs) are an important cause of illness in humans and animals. Most
human coronaviruses commonly cause relatively mild respiratory illnesses; however two …

Genomic RNA elements drive phase separation of the SARS-CoV-2 nucleocapsid

C Iserman, CA Roden, MA Boerneke, RSG Sealfon… - Molecular cell, 2020 - cell.com
We report that the SARS-CoV-2 nucleocapsid protein (N-protein) undergoes liquid-liquid
phase separation (LLPS) with viral RNA. N-protein condenses with specific RNA genomic …

The coronavirus recombination pathway

HL Wells, CM Bonavita, I Navarrete-Macias, B Vilchez… - Cell host & …, 2023 - cell.com
Recombination is thought to be a mechanism that facilitates cross-species transmission in
coronaviruses, thus acting as a driver of coronavirus spillover and emergence. Despite its …

Systematic review of the common pathophysiological mechanisms in COVID-19 and neurodegeneration: the role of bioactive compounds and natural antioxidants

K Choe, HY Park, M Ikram, HJ Lee, TJ Park, R Ullah… - Cells, 2022 - mdpi.com
The novel coronavirus (2019-nCoVCOVID-19) belongs to the Beta coronavirus family, which
contains MERS-CoV (Middle East respiratory syndrome coronavirus) and SARS-CoV …

Coronavirus cis-acting RNA elements

R Madhugiri, M Fricke, M Marz, J Ziebuhr - Advances in virus research, 2016 - Elsevier
Coronaviruses have exceptionally large RNA genomes of approximately 30 kilobases.
Genome replication and transcription is mediated by a multisubunit protein complex …

[HTML][HTML] Structural and functional conservation of cis-acting RNA elements in coronavirus 5'-terminal genome regions

R Madhugiri, N Karl, D Petersen, K Lamkiewicz… - Virology, 2018 - Elsevier
Abstract Structure predictions suggest a partial conservation of RNA structure elements in
coronavirus terminal genome regions. Here, we determined the structures of stem-loops …

Viral RNA switch mediates the dynamic control of flavivirus replicase recruitment by genome cyclization

ZY Liu, XF Li, T Jiang, YQ Deng, Q Ye, H Zhao, JY Yu… - Elife, 2016 - elifesciences.org
Viral replicase recruitment and long-range RNA interactions are essential for RNA virus
replication, yet the mechanism of their interplay remains elusive. Flaviviruses include …

[HTML][HTML] Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate

C Iserman, C Roden, M Boerneke, R Sealfon… - BioRxiv, 2020 - ncbi.nlm.nih.gov
A mechanistic understanding of the SARS-CoV-2 viral replication cycle is essential to
develop new therapies for the COVID-19 global health crisis. In this study, we show that the …

Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus

WC Hsin, CH Chang, CY Chang, WH Peng… - Journal of biomedical …, 2018 - Springer
Abstract Background Middle East respiratory syndrome coronavirus (MERS-CoV) consists of
a positive-sense, single-stranded RNA genome and four structural proteins: the spike …