The past decades of advancements in NMR have made it a very powerful tool for metabolic
research. Despite its limitations in sensitivity relative to mass spectrometric techniques, NMR …

Advances in analytical methodologies, principally nuclear magnetic resonance
spectroscopy (NMR) and mass spectrometry (MS), during the last decade have made large …

The levels of L-arginine, a cationic, semi-essential amino acid, are often controlled within a
cell at the level of local availability through biosynthesis. The importance of this temporal …

Inborn errors of metabolism are characterized by dysregulation of the metabolic networks
that underlie development and homeostasis, and constitute an important and expanding …

Systems Biology aims to understand quantitatively how properties of biological systems can
be understood as functions of the characteristics of, and interactions between their …

Nuclear magnetic resonance (NMR) and mass spectrometry (MS) together are synergistic in
their ability to profile comprehensively the metabolome of cells and tissues. In addition to …

2. Topological Network Analysis 3. Stoichiometric Analysis 4. Intermediate Approaches B.
The Rationale of Mathematical Modeling III. The Basic Concepts of Metabolic Modeling A …

This mini-review summarizes studies my associates and I carried out that are relevant to the
topic of the present volume [ie glutamate dehydrogenase (GDH)] using radioactive 13N (t1/2 …

In the last decade, the field now commonly referred to as systems biology has developed
rapidly. With the sequencing of whole genomes and the development of analysis methods to …

The Silicon Cell initiative aims to understand cellular systems on the basis of the
characteristics of their components. As a tool to achieve this, detailed kinetic models at the …