Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …

Gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) are fairly rare neoplasms
that present many clinical challenges. They secrete peptides and neuroamines that cause …

Pancreatic endocrine tumors (PETs) have long fascinated clinicians and investigators
despite their relative rarity. Their clinical presentation varies depending on whether the …

The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated
in many types of cancer. Mechanisms for pathway activation include loss of tumor …

Phosphatidylinositol 3‐kinase (PI3K) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) signaling pathway play an important role in multiple cellular …

Somatostatin receptor imaging (SRI) with [111 In-DTPA 0] octreotide has proven its role in
the diagnosis and staging of gastroenteropancreatic neuroendocrine tumors (GEPNETs) …

Purpose: 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is currently not
used on a routine basis for imaging of neuroendocrine (NE) tumors. The aim of this study …

Purpose We investigated the global gene expression in a large panel of pancreatic
endocrine tumors (PETs) aimed at identifying new potential targets for therapy and …

During the past 15 years, most large pharmaceutical companies have decreased the
screening of natural products for drug discovery in favor of synthetic compound libraries …

The serine-threonine kinase mammalian target of rapamycin (mTOR) plays a major role in
the regulation of protein translation, cell growth, and metabolism. Alterations of the mTOR …