Microbial lifelines in bioprocesses: From concept to application

L Blöbaum, C Haringa, A Grünberger - Biotechnology advances, 2023 - Elsevier
Bioprocesses are scaled up for the production of large product quantities. With larger
fermenter volumes, mixing becomes increasingly inefficient and environmental gradients get …

Sensors for disposable bioreactors

C Busse, P Biechele, I de Vries… - Engineering in Life …, 2017 - Wiley Online Library
Modern bioprocess monitoring demands sensors that provide on‐line information about the
process state. In particular, sensors for monitoring bioprocesses carried out in single‐use …

[HTML][HTML] Flow-following sensor devices: A tool for bridging data and model predictions in large-scale fermentations

J Bisgaard, M Muldbak, S Cornelissen… - Computational and …, 2020 - Elsevier
Production-scale fermentation processes in industrial biotechnology experience gradients in
process variables, such as dissolved gases, pH and substrate concentrations, which can …

Electrochemical dissolved oxygen sensor-integrated platform for wireless in situ bioprocess monitoring

JM Stine, LA Beardslee, RM Sathyam… - Sensors and Actuators B …, 2020 - Elsevier
This work presents a bio-processing online device (bPod) platform, capable of real-time in
situ monitoring of bioreactor cell culture parameters, such as dissolved oxygen (DO). The …

The impact of pH inhomogeneities on CHO cell physiology and fed‐batch process performance–two‐compartment scale‐down modelling and intracellular pH …

M Brunner, P Braun, P Doppler, C Posch… - Biotechnology …, 2017 - Wiley Online Library
Due to high mixing times and base addition from top of the vessel, pH inhomogeneities are
most likely to occur during large‐scale mammalian processes. The goal of this study was to …

Computational fluid dynamics simulation improves the design and characterization of a plug‐flow‐type scale‐down reactor for microbial cultivation processes

F Mayer, M Cserjan‐Puschmann… - Biotechnology …, 2023 - Wiley Online Library
The scale‐up of bioprocesses remains one of the major obstacles in the biotechnology
industry. Scale‐down bioreactors have been identified as valuable tools to investigate the …

Focus on dynamics of particles in turbulence

M Bourgoin, H Xu - New Journal of Physics, 2014 - iopscience.iop.org
Studies on the dynamics of particles in turbulence have recently experienced advances in
experimental techniques, numerical simulations and theoretical understandings. This' focus …

Translational and rotational dynamics of a large buoyant sphere in turbulence

V Mathai, MWM Neut, EP van der Poel, C Sun - Experiments in fluids, 2016 - Springer
We report experimental measurements of the translational and rotational dynamics of a
large buoyant sphere in isotropic turbulence. We introduce an efficient method to …

Note:“Lock-in accelerometry” to follow sink dynamics in shaken granular matter

G Sánchez-Colina, L Alonso-Llanes… - Review of scientific …, 2014 - pubs.aip.org
Understanding the penetration dynamics of intruders in granular beds is relevant not only for
fundamental physics, but also for geophysical processes and construction on sediments or …

Measurements on the fly–Introducing mobile micro-sensors for biotechnological applications

T Lauterbach, T Lüke, MJ Büker, C Hedayat… - Sensors and Actuators A …, 2019 - Elsevier
The application of standard sensor electrodes is often limited to stirred tank reactors due to
their wired nature and their large space requirement. For other cultivation systems, sensors …