The physiological heterogeneity of platelets leads to diverse responses and the formation of
discrete subpopulations upon platelet stimulation. Procoagulant platelets are an example of …

Current understanding of how platelets localize coagulation to wound sites has come mainly
from studies of a subpopulation of activated platelets. In this review, we summarize data from …

Factor XIII (FXIII) is a transglutaminase enzyme that catalyses the formation of ε-(γ-glutamyl)
lysyl isopeptide bonds into protein substrates. The plasma form, FXIIIA2B2, has an …

Background—Platelets are central to the process of hemostasis, rapidly aggregating at sites
of blood vessel injury and acting as coagulation nidus sites. On interaction with the …

While platelets have long been known to be essential for maintaining hemostasis in the
vasculature, their role in tissue repair, inflammation and innate and adaptive immunity is a …

Binding of coagulation factors to phosphatidylserine (PS)-exposing procoagulant-activated
platelets followed by formation of the membrane-dependent enzyme complexes is critical for …

Essentials• The sequence and logic of events leading to platelet procoagulant activity are
poorly understood.• Confocal time‐lapse microscopy was used to investigate activation of …

Objective—After activation at the site of vascular injury, platelets differentiate into 2
subpopulations, exhibiting either proaggregatory or procoagulant phenotype. Although the …

The interaction of plasminogen with platelets and their localization during thrombus
formation and fibrinolysis under flow are not defined. Using a novel model of whole blood …

Factor XIII (FXIII) stabilizes thrombi against fibrinolysis by cross-linking α2-antiplasmin
(α2AP) to fibrin. Cellular FXIII (FXIII-A) is abundant in platelets, but the extracellular functions …