The discovery of bioactive molecules is an expensive and time-consuming process and new
strategies are continuously searched for in order to optimize this process. Virtual Screening …

The receptor for advanced glycation end‐products (RAGE) is a cell surface transmembrane
multiligand receptor, encoded by the AGER gene. RAGE presents many transcripts, is …

Background The genetic risk factors for susceptibility to chronic obstructive pulmonary
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …

Apolipoprotein AI (apoA-I) and high-density lipoproteins (HDL) mediate reverse cholesterol
transport out of cells. Furthermore, HDL has additional protective functions, which include …

The lung has a unique relationship to cholesterol that is shaped by its singular physiology.
On the one hand, the lungs receive the full cardiac output and have a predominant …

Background Chronic obstructive pulmonary disease (COPD) is the third leading cause of
death in the United States with no effective treatment. The current diagnostic method …

Chronic obstructive pulmonary disease (COPD) is a widespread disease associated with
high rates of disability and mortality. COPD is characterized by chronic inflammation in the …

Rationale: Chronic obstructive pulmonary disease (COPD) susceptibility is in part related to
genetic variants. Most genetic studies have been focused on genome-wide common …

Background A decline in forced expiratory volume (FEV1) is a hallmark of respiratory
diseases that are an important cause of morbidity among the elderly. While some data exist …

Rationale: Lung function and chronic obstructive pulmonary disease (COPD) are heritable
traits. Genome-wide association studies (GWAS) have identified numerous pulmonary …