Osteoporosis (OP) is a major global health concern, with aging being one of the most
important risk factors. Osteoarthritis (OA) is also an age-related disorder. Patients with OP …

Abstract Purpose of Review Atypical femur fractures (AFFs) are rare subtrochanteric or
diaphyseal fractures regarded as side effects of bisphosphonates (BPs), possibly with a …

Osteoclast differentiation and function are critical targets for anti-osteoporosis treatment.
Oxidative stress also plays an important regulatory role in the differentiation of osteoclasts …

Prolonged use of antiresorptives such as the bisphosphonate alendronate (ALN) and the
RANKL inhibitor denosumab (DMAb) are associated with rare cases of atypical femoral …

Osteoporosis and fragility fractures (FFs) are considered critical health problems by the
World Health Organization (WHO) because of high morbidity, mortality, and healthcare …

This study aimed to identify differences in femur geometry between patients with
subtrochanteric/shaft atypical femur fractures (AFFs) and the general population, and to …

Despite their ability to reduce fracture-risk and increase Bone Mineral Density (BMD) in
osteoporotic women, bisphosphonates are reported to reduce formation of new bone …

Patients on bone‐modifying agents (BMAs) for bone metastases are at risk of atypical
femoral fractures (AFFs), which can lead to a sudden deterioration in performance status. In …

Background: Increased anterolateral bowing of the femur is associated with atypical femoral
fractures among older patients (including both those receiving and those not receiving …

The earliest reports of atypical femur fractures (AFF) emerged from Asia. In the West,
epidemiologic studies report a greater incidence of AFFs among subjects of Asian …