There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …

Dominant missense pathogenic variants in cardiac myosin heavy chain cause hypertrophic
cardiomyopathy (HCM), a currently incurable disorder that increases risk for stroke, heart …

Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and
defined by unexplained isolated progressive myocardial hypertrophy, systolic and diastolic …

Aims Sarcomeric gene mutations frequently underlie hypertrophic cardiomyopathy (HCM), a
prevalent and complex condition leading to left ventricle thickening and heart dysfunction …

Importance Patients with hypertrophic obstructive cardiomyopathy (HOCM) and drug-
refractory symptoms and outflow gradients have limited nonsurgical treatment options. The …

Hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease,
associated with over 1,000 mutations, many in β-cardiac myosin (MYH7). Molecular studies …

Cardiovascular genetics is a rapidly evolving subspecialty within cardiovascular medicine,
and its growth is attributed to advances in genome sequencing and genetic testing and the …

Background Hypertrophic cardiomyopathy (HCM) is the most common inherited
cardiovascular disease that affects approximately one in 500 people. HCM is a recognized …

With the development and advancement of next-generation sequencing (NGS), genetic
analysis is becoming more accessible. High-throughput genetic studies using NGS have …

The identification of independent risk factors for HCM-related SCD would likely contribute to
risk stratification. However, it is difficult to predict SCD with absolute certainty, as the annual …