RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

Although leukemia is the most common childhood cancer diagnosis, the subtype, acute
myeloid leukemia (AML), is less common and fewer etiologic studies exist. This review …

We evaluated the frequency, genetic architecture, clinico-pathologic features and prognostic
impact of RUNX1 mutations in 2439 adult patients with newly-diagnosed acute myeloid …

First reported in 1999, germline runt-related transcription factor 1 (RUNX1) mutations are a
well-established cause of familial platelet disorder with predisposition to myeloid …

The inclusion of familial myeloid malignancies as a separate disease entity in the revised
WHO classification has renewed efforts to improve the recognition and management of this …

Myelodysplastic syndrome (MDS) is a clonal blood disorder characterized by ineffective
hematopoiesis, cytopenias, dysplasia and an increased risk of acute myeloid leukemia …

Hereditary platelet disorders (HPDs) are a group of blood disorders with variable severity
and clinical impact. Although phenotypically there is much overlap, known genetic causes …

Familial cases of myelodysplastic syndromes are rare, but are immensely valuable for the
investigation of the molecular pathogenesis of myelodysplasia in general. The best …

Since its discovery from a translocation in leukemias, the runt-related transcription factor
1/acute myelogenous leukemia-1 (RUNX1/AML1), which is widely expressed in …

Transcription factors regulate gene networks controlling normal hematopoiesis and are
frequently deregulated in acute myeloid leukemia (AML). Critical to our understanding of the …