Abstract Calcium (Ca2+) is a ubiquitous mediator of a multitude of cellular functions in the
central nervous system (CNS). Intracellular Ca2+ is tightly regulated by cells, including entry …

Neuronal cell death as a prominent pathological feature contributes to cognitive decline and
memory loss in Alzheimer's disease. We investigated the role of two forms of cell death …

Motivation Alzheimer's disease (AD) is a serious degenerative brain disease and the most
common cause of dementia. The current available drugs for AD provide symptomatic benefit …

Mature granule cells are poorly excitable neurons that were recently shown to fire action
potentials, preferentially in bursts. It is believed that the particularly pronounced short-term …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is the main form
of dementia. Abnormal deposition of amyloid-beta (Aβ) peptides in neurons and synapses …

Entorhinal cortex (EC) is one of the first cerebral regions affected in Alzheimer's disease
(AD). The pathology propagates to neighboring cerebral regions through a prion-like …

DEVELOPMENT OF NON-TRANSGENIC ANIMAL MODELS OF ALZHEIMER’S DISEASE AND
INVESTIGATION OF DRUG CANDIDATES FOR ITS TREATMENT Page 1 University of Szeged …

The central noradrenergic (NA) system is critical for maintenance of attention, behavioral
flexibility, spatial navigation, and learning and memory, those cognitive functions lost first in …

Electrophysiology is the field of study that examines physiological signals of the brain. It
ranges from assessment of molecular activity using patch clamp techniques to population …

Methods: Aβ (1 µg/2 μl) was injected into the right EC of male Wistar rats under stereotaxic
surgery, and then a guide cannula was planted in the right ventricle. Isradipine and …