Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
Immunology of aging: the birth of inflammaging
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
Interconnections between inflammageing and immunosenescence during ageing
Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …
Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
NA Duggal, G Niemiro, SDR Harridge… - Nature Reviews …, 2019 - nature.com
Remodelling of the immune system with age—immunosenescence—is a substantial
contributor to poor health in older adults, with increasing risk of infections, cancer and …
contributor to poor health in older adults, with increasing risk of infections, cancer and …
I mmunosenescence and inflammaging: risk factors of severe COVID-19 in older people
Old individuals are more susceptible to various infections due to immunological changes
that occur during the aging process. These changes named collectively as …
that occur during the aging process. These changes named collectively as …
The impact of ageing on monocytes and macrophages
RPH De Maeyer, ES Chambers - Immunology letters, 2021 - Elsevier
Ageing is a global burden. Increasing age is associated with increased incidence of
infections and cancer and decreased vaccine efficacy. This increased morbidity observed …
infections and cancer and decreased vaccine efficacy. This increased morbidity observed …
Aging and lung disease
SJ Cho, HW Stout-Delgado - Annual review of physiology, 2020 - annualreviews.org
People worldwide are living longer, and it is estimated that by 2050, the proportion of the
world's population over 60 years of age will nearly double. Natural lung aging is associated …
world's population over 60 years of age will nearly double. Natural lung aging is associated …
[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …
valuable method for identifying elderly people at risk for increased vulnerability, disease …
The relevance of a physical active lifestyle and physical fitness on immune defense: mitigating disease burden, with focus on COVID-19 consequences
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a fast spreading
virus leading to the development of Coronavirus Disease-2019 (COVID-19). Severe and …
virus leading to the development of Coronavirus Disease-2019 (COVID-19). Severe and …