The Filoviridae are a family of negative-strand RNA viruses that include several important
human pathogens. Ebola virus (EBOV) and Marburg virus are well-known filoviruses which …

Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion
bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient …

Ebola virus is a highly pathogenic filovirus causing severe hemorrhagic fever with high
mortality rates. It assembles heterogenous, filamentous, enveloped virus particles containing …

Ebola virus (EBOV) is a dangerous zoonotic infectious disease. To date, more than 25 EBOV
outbreaks have been documented, the majority of which have occurred in Central Africa …

Work with infectious Ebola viruses is restricted to biosafety level 4 (BSL4) laboratories,
presenting a significant barrier for studying these viruses. Life cycle modeling systems …

Here, we used a biologically contained Ebola virus system to characterize the spatio-
temporal distribution of Ebola virus proteins and RNA during virus replication. We found that …

Kelch-like ECH-associated protein 1 (Keap1) is a ubiquitin E3 ligase specificity factor that
targets transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) for ubiquitination …

Viral pathogenesis in the infected cell is a balance between antiviral responses and
subversion of host-cell processes. Many viral proteins specifically interact with host-cell …

Filovirus-infected cells are characterized by typical cytoplasmic inclusion bodies (IBs)
located in the perinuclear region. The formation of these IBs is induced mainly by the …

Ebola virus causes devastating hemorrhagic fever outbreaks for which no approved
therapeutic exists. The viral nucleocapsid, which is minimally composed of the proteins NP …