Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
TH Stracker, T Usui, JHJ Petrini - DNA repair, 2009 - Elsevier
The cellular DNA damage response (DDR) is activated by many types of DNA lesions. Upon
recognition of DNA damage by sensor proteins, an intricate signal transduction network is …
recognition of DNA damage by sensor proteins, an intricate signal transduction network is …
Grading the commercial optical biosensor literature—Class of 2008:'The Mighty Binders'
RL Rich, DG Myszka - Journal of Molecular Recognition: An …, 2010 - Wiley Online Library
Optical biosensor technology continues to be the method of choice for label‐free, real‐time
interaction analysis. But when it comes to improving the quality of the biosensor literature …
interaction analysis. But when it comes to improving the quality of the biosensor literature …
Acetylation regulates ribonucleotide reductase activity and cancer cell growth
Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside
diphosphates (dNDPs) to provide dNTP precursors for DNA synthesis. Here, we report that …
diphosphates (dNDPs) to provide dNTP precursors for DNA synthesis. Here, we report that …
Structure and function of the phosphothreonine-specific FHA domain
A Mahajan, C Yuan, H Lee, ESW Chen, PY Wu… - Science …, 2008 - science.org
The forkhead-associated (FHA) domain is the only known phosphoprotein-binding domain
that specifically recognizes phosphothreonine (pThr) residues, distinguishing them from …
that specifically recognizes phosphothreonine (pThr) residues, distinguishing them from …
Two faces of CwlM, an essential PknB substrate, in Mycobacterium tuberculosis
Tuberculosis claims> 1 million lives annually, and its causative agent Mycobacterium
tuberculosis is a highly successful pathogen. Protein kinase B (PknB) is reported to be …
tuberculosis is a highly successful pathogen. Protein kinase B (PknB) is reported to be …
FHA domains: Phosphopeptide binding and beyond
Forkhead-associated (FHA) domains are small phosphopeptide recognition modules found
in eubacterial and eukaryotic, but not archeal, genomes. Although they were originally found …
in eubacterial and eukaryotic, but not archeal, genomes. Although they were originally found …
The FHA domain protein ArnA functions as a global DNA damage response repressor in the hyperthermophilic archaeon Saccharolobus islandicus
Z Jiang, Z Lin, Q Gan, P Wu, X Zhang, Y Xiao, Q She… - Mbio, 2023 - Am Soc Microbiol
Forkhead-associated (FHA) domain proteins specifically recognize phosphorylated
threonine via the FHA domain and are involved in signal transduction in various processes …
threonine via the FHA domain and are involved in signal transduction in various processes …
Recruitment of Saccharomyces cerevisiae Dnl4–Lif1 Complex to a Double-Strand Break Requires Interactions With Yku80 and the Xrs2 FHA Domain
PL Palmbos, D Wu, JM Daley, TE Wilson - Genetics, 2008 - academic.oup.com
Nonhomologous end joining (NHEJ) in yeast depends on eight different proteins in at least
three different functional complexes: Yku70–Yku80 (Ku), Dnl4–Lif1–Nej1 (DNA ligase IV) …
three different functional complexes: Yku70–Yku80 (Ku), Dnl4–Lif1–Nej1 (DNA ligase IV) …
Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK
AAE Ali, RM Jukes, LH Pearl… - Nucleic acids research, 2009 - academic.oup.com
Short-patch repair of DNA single-strand breaks and gaps (SSB) is coordinated by XRCC1, a
scaffold protein that recruits the DNA polymerase and DNA ligase required for filling and …
scaffold protein that recruits the DNA polymerase and DNA ligase required for filling and …
Fha Interaction with Phosphothreonine of TssL Activates Type VI Secretion in Agrobacterium tumefaciens
The type VI secretion system (T6SS) is a widespread protein secretion system found in many
Gram-negative bacteria. T6SSs are highly regulated by various regulatory systems at …
Gram-negative bacteria. T6SSs are highly regulated by various regulatory systems at …