A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity
Karyopherin-β2 (Kapβ2) is a nuclear-import receptor that recognizes proline-tyrosine
nuclear localization signals of diverse cytoplasmic cargo for transport to the nucleus. Kapβ2 …
nuclear localization signals of diverse cytoplasmic cargo for transport to the nucleus. Kapβ2 …
Conserved loop of a phase modifier endows protein condensates with fluidity
H Kawamukai, M Matsusaki, T Tanimoto, M Watabe… - bioRxiv, 2024 - biorxiv.org
Dipeptide repeats (DPRs) that are gene products from abnormal hexanucleotide repeat
expansion in C9orf72 trigger amyotrophic lateral sclerosis (ALS) through unknown …
expansion in C9orf72 trigger amyotrophic lateral sclerosis (ALS) through unknown …
ENGINEERING KAPβ2 TO DISAGGREGATE DISEASE-ASSOCIATED PROTEINS
C Fare - 2022 - repository.upenn.edu
Neurodegenerative diseases result from a failure to maintain proteostasis, and a major
hallmark of neurodegeneration is the accumulation of aggregated protein deposits in the …
hallmark of neurodegeneration is the accumulation of aggregated protein deposits in the …