Skeletal muscle is a crucial tissue for movement, gestural assistance, metabolic
homeostasis, and thermogenesis. It makes up approximately 40% of the total body weight …

The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …

More people die from cardiovascular diseases (CVD) than from any other cause.
Cardiovascular complications are thought to arise from enhanced levels of free radicals …

Aims Heart failure is a major complication in cancer treatment due to the cardiotoxic effects
of anticancer drugs, especially from the anthracyclines such as doxorubicin (DXR). DXR …

SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-
DEAF1) domain-containing protein 2 (SMYD2) is a protein methyltransferase that methylates …

The giant protein titin is thought to be required for sarcomeric integrity in mature myocytes,
but direct evidence for this hypothesis is limited. Here, we describe a mouse model in which …

Fluorouracil (5-Fu) is a first-line drug for colorectal cancer (CRC) therapy. However, the
development of 5-Fu resistance limits its chemotherapeutic effectiveness and often leads to …

The anthracycline doxorubicin (DOX) is widely used in cancer therapy with the limitation of
cardiotoxicity leading to the development of congestive heart failure. DOX-induced oxidative …

Reactive oxygen species (ROS) have been implicated in mechanisms of heart development
and regenerative therapies such as the use of pluripotent stem cells. The roles of ROS …

Muscle specific signaling has been shown to originate from myofilaments and their
associated cellular structures, including the sarcomeres, costameres or the cardiac …