Emerging approaches to DNA data storage: challenges and prospects

A Doricchi, CM Platnich, A Gimpel, F Horn, M Earle… - ACS …, 2022 - ACS Publications
With the total amount of worldwide data skyrocketing, the global data storage demand is
predicted to grow to 1.75× 1014 GB by 2025. Traditional storage methods have difficulties …

Propelling DNA computing with materials' power: Recent advancements in innovative DNA logic computing systems and smart bio‐applications

D Fan, J Wang, E Wang, S Dong - Advanced Science, 2020 - Wiley Online Library
DNA computing is recognized as one of the most outstanding candidates of next‐generation
molecular computers that perform Boolean logic using DNAs as basic elements. Benefiting …

DNA-based programmable gate arrays for general-purpose DNA computing

H Lv, N Xie, M Li, M Dong, C Sun, Q Zhang, L Zhao… - Nature, 2023 - nature.com
The past decades have witnessed the evolution of electronic and photonic integrated
circuits, from application specific to programmable,. Although liquid-phase DNA circuitry …

Nonlinear decision-making with enzymatic neural networks

S Okumura, G Gines, N Lobato-Dauzier, A Baccouche… - Nature, 2022 - nature.com
Artificial neural networks have revolutionized electronic computing. Similarly, molecular
networks with neuromorphic architectures may enable molecular decision-making on a level …

Universal and programmable rolling circle amplification-CRISPR/Cas12a-mediated immobilization-free electrochemical biosensor

M Qing, SL Chen, Z Sun, Y Fan, HQ Luo… - Analytical …, 2021 - ACS Publications
The development of a sensing platform with high sensitivity and specificity, especially
programmability and universal applicability, for the detection of clinically relevant molecules …

Implementing digital computing with DNA-based switching circuits

F Wang, H Lv, Q Li, J Li, X Zhang, J Shi, L Wang… - Nature …, 2020 - nature.com
DNA strand displacement reactions (SDRs) provide a set of intelligent toolboxes for
developing molecular computation. Whereas SDR-based logic gate circuits have achieved a …

The compact integration of a cascaded HCR circuit for highly reliable cancer cell discrimination

P Dong, R Li, S He, Q Zhang, J Shang, Y Jiang… - Chemical …, 2023 - pubs.rsc.org
The accurate identification of multiple biomarkers involved in disease plays a vital role in
effectively distinguishing cancer cells from normal cells, facilitating reliable cancer …

DNA logic circuits for cancer theranostics

J Chen, S Fu, C Zhang, H Liu, X Su - Small, 2022 - Wiley Online Library
Cancer diagnosis and therapeutics (theranostics) based on the tumor microenvironment
(TME) and biomarkers has been an emerging approach for precision medicine. DNA …

Cascade strand displacement and bipedal walking based DNA logic system for miRNA diagnostics

P Miao, Y Tang - ACS Central Science, 2021 - ACS Publications
DNA logic gated operations empower the highly efficient analysis of multiplex nucleic acid
inputs, which have attracted extensive attention. However, the integration of DNA logic gates …

Non-complementary strand commutation as a fundamental alternative for information processing by DNA and gene regulation

MP Nikitin - Nature Chemistry, 2023 - nature.com
The discovery of the DNA double helix has revolutionized our understanding of data
processing in living systems, with the complementarity of the two DNA strands providing a …